M
Markus P. Kummer
Researcher at University of Bonn
Publications - 55
Citations - 12587
Markus P. Kummer is an academic researcher from University of Bonn. The author has contributed to research in topics: Amyloid precursor protein & Neuroinflammation. The author has an hindex of 35, co-authored 54 publications receiving 9821 citations. Previous affiliations of Markus P. Kummer include University Hospital Bonn & University of California, San Diego.
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Journal ArticleDOI
Neuroinflammation in Alzheimer's disease
Michael T. Heneka,Monica J. Carson,Joseph El Khoury,Gary E. Landreth,Frederic Brosseron,Douglas L. Feinstein,Andreas H. Jacobs,Tony Wyss-Coray,Tony Wyss-Coray,Javier Vitorica,Richard M. Ransohoff,Karl Herrup,Sally A. Frautschy,Bente Finsen,Guy C. Brown,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky,Koji Yamanaka,Jari Koistinaho,Eicke Latz,Eicke Latz,Annett Halle,Gabor C. Petzold,Terrence Town,Dave Morgan,Mari L. Shinohara,V. Hugh Perry,Clive Holmes,Clive Holmes,Nicolas G. Bazan,David J. Brooks,Stéphane Hunot,Bertrand Joseph,Nikolaus Deigendesch,Olga Garaschuk,Erik Boddeke,Charles A. Dinarello,John C.S. Breitner,Greg M. Cole,Douglas T. Golenbock,Markus P. Kummer +41 more
TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.
Journal ArticleDOI
NLRP3 is activated in Alzheimer´s disease and contributes to pathology in APP/PS1 mice
Michael T. Heneka,Markus P. Kummer,Andrea Stutz,Andrea Delekate,Stephanie Schwartz,Ana Vieira-Saecker,Angelika Griep,Daisy Axt,Anita Remus,Te-Chen Tzeng,Ellen Gelpi,Annett Halle,Martin Korte,Eicke Latz,Eicke Latz,Douglas T. Golenbock +15 more
TL;DR: The role of the NLRP3/caspase-1 axis in the pathogenesis of Alzheimer's disease was investigated in this article, which showed an important role for the inflammasome.
Journal ArticleDOI
Innate immune activation in neurodegenerative disease
TL;DR: How the activation of innate immune signalling pathways — in particular, the NOD-, LRR- and pyrin domain-containing 3 (NLRP3) inflammasome — by aberrant host proteins may be a common step in the development of diverse neurodegenerative disorders is discussed.
Journal ArticleDOI
Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease
Carmen Venegas,Sathish Kumar,Bernardo S. Franklin,Tobias Dierkes,Rebecca Brinkschulte,Dario Tejera,Ana Vieira-Saecker,Stephanie Schwartz,Francesco Santarelli,Markus P. Kummer,Angelika Griep,Ellen Gelpi,Michael Beilharz,Dietmar Riedel,Douglas T. Golenbock,Matthias Geyer,Jochen Walter,Eicke Latz,Eicke Latz,Michael T. Heneka,Michael T. Heneka +20 more
TL;DR: Findings support the concept that inflammasome activation is connected to seeding and spreading of amyloid-β pathology in patients with Alzheimer’s disease.
Journal ArticleDOI
Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine
Michael T. Heneka,Fabian Nadrigny,Tommy Regen,Ana Martinez-Hernandez,Lucia Dumitrescu-Ozimek,Dick Terwel,Daniel Jardanhazi-Kurutz,Jochen Walter,Frank Kirchhoff,Uwe-Karsten Hanisch,Markus P. Kummer +10 more
TL;DR: It is indicated that decrease of NE in locus ceruleus projection areas facilitates the inflammatory reaction of microglial cells in AD and impairs microglia migration and phagocytosis, thereby contributing to reduced Aβ clearance.