Journal ArticleDOI
Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.
James C. Grotta,M Kothari,K.M.A. Welch,Joseph P. Broderick,Barbara C. Tilley,Thomas G. Brott,Marler,Patrick D. Lyden,Paul M. O'Byrne +8 more
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This article is published in The New England Journal of Medicine.The article was published on 1995-12-13. It has received 9299 citations till now. The article focuses on the topics: Tissue plasminogen activator & Stroke.read more
Citations
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Journal ArticleDOI
Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
Aram V. Chobanian,George L. Bakris,Henry R. Black,William C. Cushman,Lee A. Green,Joseph L. Izzo,Daniel W. Jones,Barry J. Materson,Suzanne Oparil,Jackson T. Wright,Edward J. Roccella +10 more
TL;DR: In those older than age 50, systolic blood pressure of greater than 140 mm Hg is a more important cardiovascular disease (CVD) risk factor than diastolic BP, and hypertension will be controlled only if patients are motivated to stay on their treatment plan.
Journal ArticleDOI
Guidelines for the Early Management of Patients With Acute Ischemic Stroke A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
William J. Powers,Alejandro A. Rabinstein,Teri Ackerson,Opeolu Adeoye,Nicholas C. Bambakidis,Kyra J. Becker,José Biller,Michael D. Brown,Bart M. Demaerschalk,Brian L. Hoh,Edward C. Jauch,Chelsea S. Kidwell,Thabele M Leslie-Mazwi,Bruce Ovbiagele,Phillip A. Scott,Kevin N. Sheth,Andrew M. Southerland,Deborah V. Summers,David L. Tirschwell +18 more
TL;DR: These guidelines supersede the prior 2007 guidelines and 2009 updates and support the overarching concept of stroke systems of care and detail aspects of stroke care from patient recognition; emergency medical services activation, transport, and triage; through the initial hours in the emergency department and stroke unit.
Journal ArticleDOI
Thrombolysis with Alteplase 3 to 4.5 Hours After Acute Ischemic Stroke
Werner Hacke,Markku Kaste,Erich Bluhmki,Miroslav Brozman,Antoni Dávalos,Donata Guidetti,Vincent Larrue,Kennedy R. Lees,Zakaria Medeghri,Thomas Machnig,Dietmar Schneider,Rüdiger von Kummer,Nils Wahlgren,Danilo Toni +13 more
TL;DR: As compared with placebo, intravenous alteplase administered between 3 and 4.5 hours after the onset of symptoms significantly improved clinical outcomes in patients with acute ischemic stroke; altePlase was more frequently associated with symptomatic intracranial hemorrhage.
Journal ArticleDOI
Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke
Mayank Goyal,Muneer Eesa,John Thornton,Denis-Claude Roy,Dar Dowlatshahi,Ashfaq Shuaib,D. Tampieri,David Williams,H. Choe,Brian T. Jankowitz,Michael Kelly,Guillermo Linares,Jai Jai Shiva Shankar,Alain Weill,Suresh Subramaniam,Abstr Act +15 more
TL;DR: In this paper, the authors evaluated rapid endovascular treatment in addition to standard care in patients with acute ischemic stroke with a small infarct core, a proximal intracranial arterial occlusion, and moderate-to-good collateral circulation.
Journal ArticleDOI
2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
Paul K. Whelton,Robert M. Carey,Wilbert S. Aronow,Donald E. Casey,Karen J. Collins,Cheryl Dennison Himmelfarb,Sondra M. DePalma,Samuel S. Gidding,Kenneth Jamerson,Daniel W. Jones,Eric J. MacLaughlin,Paul Muntner,Bruce Ovbiagele,Sidney C. Smith,Crystal C. Spencer,Randall S. Stafford,Sandra J. Taler,Randal J. Thomas,Kim A. Williams,Jeff D. Williamson,Jackson T. Wright +20 more
TL;DR: Since 1980, the American College of Cardiology and American Heart Association have translated scientific evidence into clinical practice guidelines (guidelines) with recommendations to improve cardiovascular health.
References
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Longitudinal data analysis for discrete and continuous outcomes.
Scott L. Zeger,Kung-Yee Liang +1 more
TL;DR: A class of generalized estimating equations (GEEs) for the regression parameters is proposed, extensions of those used in quasi-likelihood methods which have solutions which are consistent and asymptotically Gaussian even when the time dependence is misspecified as the authors often expect.
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Interobserver agreement for the assessment of handicap in stroke patients.
TL;DR: The results confirm the value of the modified Rankin scale in the assessment of handicap in stroke patients; nevertheless, further improvements are possible.
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A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
Journal ArticleDOI
Improved reliability of the NIH Stroke Scale using video training. NINDS TPA Stroke Study Group.
Patrick D. Lyden,Thomas Brott,Barbara C. Tilley,K.M.A. Welch,Edward J. Mascha,Steven R. Levine,E. C. Haley,James C. Grotta,John R. Marler +8 more
TL;DR: Video training and certification is a practical and effective method to standardize the use of examination scales in a study of acute stroke therapy so that all examiners rated patients comparably.
Journal ArticleDOI
Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke
Gregory J. del Zoppo,Klaus Poeck,Michael S. Pessin,Samuel M. Wolpert,Anthony J. Furlan,Andreas Ferbert,Mark J. Alberts,Justin A. Zivin,Lawrence R. Wechsler,Otto Busse,Ralph G. Greenlee,Lawrence M. Brass,Jay P. Mohr,Edward Feldmann,Werner Hacke,Carlos S. Kase,José Biller,Daryl R. Gress,Shirley M. Otis +18 more
TL;DR: It is indicated that site of occlusion, time to recanalization, and time to treatment are important variables in acute stroke intervention with this agent.
Related Papers (5)
Guidelines for the Early Management of Patients With Acute Ischemic Stroke A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
William J. Powers,Alejandro A. Rabinstein,Teri Ackerson,Opeolu Adeoye,Nicholas C. Bambakidis,Kyra J. Becker,José Biller,Michael D. Brown,Bart M. Demaerschalk,Brian L. Hoh,Edward C. Jauch,Chelsea S. Kidwell,Thabele M Leslie-Mazwi,Bruce Ovbiagele,Phillip A. Scott,Kevin N. Sheth,Andrew M. Southerland,Deborah V. Summers,David L. Tirschwell +18 more