Journal ArticleDOI
Pathological mechanisms and therapeutic strategies for Alzheimer's disease.
Yaojun Ju,Kin Yip Tam +1 more
Reads0
Chats0
TLDR
A review of representative treatments targeting different pathological pathways currently under clinical evaluations can be found in this paper, where the authors highlight multi-target therapies as an emerging strategy for Alzheimer's disease treatment.About:
This article is published in Neural Regeneration Research.The article was published on 2022-03-01. It has received 110 citations till now. The article focuses on the topics: Disease & Amyloid beta.read more
Citations
More filters
Journal ArticleDOI
Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System
Raluca Ioana Teleanu,Adelina-Gabriela Niculescu,Eugenia Roza,Oana Vladacenco,Alexandru Mihai Grumezescu,Daniel Mihai Teleanu +5 more
TL;DR: The present paper aims to describe the most important neurotransmitters, broadly classified into canonical (e.g., amino acids, monoamines, acetylcholine, purines, soluble gases, neuropeptides) and noncanonical neurotransmits, and explain their link with some of the most relevant neurological conditions.
Journal ArticleDOI
Role of Microglia and Astrocytes in Alzheimer’s Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation
Giulia Di Benedetto,Chiara Burgaletto,Carlo Maria Bellanca,Antonio Munafò,Renato Bernardini,Giuseppina Cantarella +5 more
TL;DR: An overview of the current understanding of the interactions between the glia cells-mediated inflammatory responses and the molecular mechanisms involved in Ca2+ homeostasis dysregulation in AD is provided.
Journal ArticleDOI
Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease.
TL;DR: Based on the recent research focus on the novel cholinesterase inhibitors with multiple bio-functions, a review aims at summarizing and discussing the most recent studies excavating the potential carbamate-based MTDLs with choline inhibition efficacy, to accelerate the pace of pleiotropic choline-based inhibitors for coping Alzheimer's disease as discussed by the authors .
Journal ArticleDOI
New insights into the role and mechanisms of ginsenoside Rg1 in the management of Alzheimer's disease.
Jiao Wu,Yu Yang,Yang Wan,Jia Xia,Jin-feng Xu,Li Zhang,Yongmei Liu,Lu Chen,Fei Tang,Huifang Ao,Cheng Peng +10 more
TL;DR: In this article , a comprehensive review of the effects and underlying mechanisms of ginsenoside Rg1 on AD has been provided, which shed light on the future directions in the utilization and development of anti-AD drugs.
Journal ArticleDOI
Therapeutic Effects of Green Tea Polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis
TL;DR: The most abundant polyphenol in green tea, Epigallocatechin-3-gallate (EGCG), possesses a wide variety of anti-inflammatory, antioxidant, antifibrotic, anti-remodelation, and tissue-protective properties which may be useful in the treatment of various diseases, particularly in cancer, and neurological, cardiovascular, respiratory, and metabolic disorders as discussed by the authors .
References
More filters
Journal ArticleDOI
Amyloid plaque core protein in Alzheimer disease and Down syndrome
Colin L. Masters,Gail Simms,Nicola A. Weinman,Gerd Multhaup,Brian L. McDonald,Konrad Beyreuther +5 more
TL;DR: The shared 4-kDa subunit indicates a common origin for the amyloids of the plaque core and of the congophilic angiopathy of Alzheimer disease and Down syndrome.
Journal ArticleDOI
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Karen Hsiao,Paul F. Chapman,Steven P. Nilsen,Chris Eckman,Yasuo Harigaya,Steven G. Younkin,Fusheng Yang,Greg M. Cole +7 more
TL;DR: Transgenic mice overexpressing the 695-amino acid isoform of human Alzheimer β-amyloid (Aβ) precursor protein containing a Lys670 → Asn, Met671 → Leu mutation had normal learning and memory but showed impairment by 9 to 10 months of age.
Journal ArticleDOI
Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment.
Robert D. Terry,Eliezer Masliah,David P. Salmon,Nelson Butters,Richard DeTeresa,Robert Hill,Lawrence A. Hansen,Robert Katzman +7 more
TL;DR: Both linear regressions and multivariate analyses correlating three global neuropsychological tests with a number of structural and neurochemical measurements performed on a prospective series of patients with Alzheimer's disease and 9 neuropathologically normal subjects reveal very powerful correlations with all three psychological assays.
Journal ArticleDOI
The amyloid hypothesis of Alzheimer's disease at 25 years
Dennis J. Selkoe,John Hardy +1 more
TL;DR: In a recent study, this article showed that low cerebrospinal fluid (CSF) Aβ42 and amyloid-PET positivity precede other AD manifestations by many years.
Journal ArticleDOI
Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils
TL;DR: The hypothesis that Aβ42 fibrils can accelerate NFT formation in vivo is supported, and NFTs that contained tau phosphorylated at serine 212/threonine 214 and serine 422 were identified.