Pax6 Controls the Expression of Critical Genes Involved in Pancreatic α Cell Differentiation and Function
Yvan Gosmain,Eric Marthinet,Claire Cheyssac,Audrey Guérardel,Aline Mamin,Liora S. Katz,Karim Bouzakri,Jacques Philippe +7 more
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TLDR
It is concluded that Pax6 is critical for α cell function and differentiation through the transcriptional control of key genes involved in glucagon gene transcription, proglucagon processing, and α cell differentiation.About:
This article is published in Journal of Biological Chemistry.The article was published on 2010-10-22 and is currently open access. It has received 71 citations till now. The article focuses on the topics: Cellular differentiation & Promoter.read more
Citations
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The Human Protein Atlas as a proteomic resource for biomarker discovery
TL;DR: The Human Protein Atlas as a proteomic resource for biomarker discovery and its applications in medicine and drug discovery are reviewed.
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Context-specific α-to-β-cell reprogramming by forced Pdx1 expression
TL;DR: It is revealed that Pdx1 can work single-handedly as a potent context-dependent autonomous reprogramming agent, and a postnatal differentiation evaluation stage involved in normal endocrine maturation is suggested.
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Pax6: A multi-level regulator of ocular development
TL;DR: The regulation of Pax6's expression pattern, the protein's DNA-binding properties, and its specific roles and mechanisms of action at all stages of lens and retinal development are described.
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Pax6 Is Crucial for β-Cell Function, Insulin Biosynthesis, and Glucose-Induced Insulin Secretion
Yvan Gosmain,Liora S. Katz,Mounia Heddad Masson,Claire Cheyssac,Caroline Poisson,Jacques Philippe +5 more
TL;DR: The results strongly suggest that Pax6 is crucial forβ-cells through transcriptional control of key genes coding for proteins that are involved in insulin biosynthesis and secretion as well as glucose and incretin actions on β-cells.
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Deconstructing Pancreas Developmental Biology
TL;DR: How classical cell biology, genetic analysis, lineage tracing, and embryological investigations are being complemented by powerful modern methods including epigenetic analysis, time-lapse imaging, and flow cytometry-based cell purification to dissect fundamental processes of pancreas development are described.
References
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Pax-6, a murine paired box gene, is expressed in the developing CNS.
Claudia Walther,Peter Gruss +1 more
TL;DR: The expression pattern of Pax-6 during embryogenesis and the isolation of cDNA clones spanning the entire coding region are described and, in addition to the paired domain, a paired-type homeodomain is contained.
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The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer.
Vijay Kumar,Pierre Chambon +1 more
TL;DR: In addition to inducing the activation function associated with the HBD, estrogen plays a crucial role in the formation of stable ER dimers that bind tightly to ERE.
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Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice
Francisco J. Naya,Hsiang-Po Huang,Yuhong Qiu,Hiroyuki Mutoh,Francesco J. DeMayo,Andrew B. Leiter,Ming-Jer Tsai +6 more
TL;DR: BETA2 is critical for the normal development of several specialized cell types arising from the gut endoderm, and the absence of these two pancreatic secretagogs may explain the abnormal cellular polarity and inability to secrete zymogen granules in pancreatic acinar exocrine cells.
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Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas.
TL;DR: It is concluded that both Pax genes are required for endocrine fate in the pancreas after showing that the paired-box gene Pax6 is expressed during the early stages of pancreatic development and in mature endocrine cells.
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Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells
TL;DR: Results indicate that ISL1, by virtue of its requirement for the formation of dorsal mesenchyme, is necessary for the development of the dorsal exocrine pancreas, and also thatISL1 function in pancreatic endodermal cells is required for the generation of all endocrine islet cells.