Journal ArticleDOI
Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling.
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TLDR
The peroxiredoxin (Prx) enzyme as mentioned in this paper is an enzyme that protects against oxidation in a thiol-containing system and was shown to reduce hydroperoxides and peroxynitrite with the use of electrons provided by a physiological thiol like thioredoxin.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2005-06-15. It has received 1351 citations till now. The article focuses on the topics: Cysteine sulfinic acid & Peroxiredoxin.read more
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Reactive oxygen species, cellular redox systems and apoptosis
Magdalena L. Circu,Tak Yee Aw +1 more
TL;DR: A full understanding of the redox control of apoptotic initiation and execution could underpin the development of therapeutic interventions targeted at oxidative stress-associated disorders.
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Oxidative stress and neurodegeneration: where are we now?
TL;DR: After a long lag period, therapeutic and other interventions based on a knowledge of redox biology are on the horizon for at least some of the neurodegenerative diseases.
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Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic Life
TL;DR: The field of antioxidants and free radicals is often perceived as focusing around the use of antioxidant supplements to prevent human disease, but in fact, antioxidants/free radicals permeate the whole of life, creating the field of redox biology.
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Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production
TL;DR: O Ongoing research continues to probe the mechanisms by which oxidants influence skeletal muscle contractile properties and to explore interventions capable of protecting muscle from oxidant-mediated dysfunction.
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Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
TL;DR: This Review focuses on pharmacological strategies to attenuate the toxic effects of peroxynitrite, which include its catalytic reduction to nitrite and its isomerization to nitrate by metalloporphyrins, which have led to potential candidates for drug development for cardiovascular, inflammatory and neurodegenerative diseases.
References
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Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
TL;DR: Peroxynitrite anion was a less effective thiol-oxidizing agent than its anion, with oxidation presumably mediated by the decomposition products, hydroxyl radical and nitrogen dioxide.
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Structure, mechanism and regulation of peroxiredoxins
TL;DR: Using crystal structures, a detailed catalytic cycle has been derived for typical 2-Cys Prxs, including a model for the redox-regulated oligomeric state proposed to control enzyme activity.
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Peroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling
TL;DR: It is suggested that this adaptation allows 2-Cys Prxs to act as floodgates, keeping resting levels of hydrogen peroxide low, while permitting higher levels during signal transduction, and is proposed to be the structural origins of sensitivity.
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Oxygen radicals and signaling
TL;DR: The progress in understanding the intracellular pathways leading from ligand stimulation to the generation of oxidants, as well as some of the increasing number of cellular processes that appear to be subject to redox regulation are discussed.
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Thioredoxin-dependent peroxide reductase from yeast.
TL;DR: The Saccharomyces cerevisiae thioredoxin reductase gene was also cloned and sequenced, and the deduced amino sequence was shown to be 51% identical with that of the Escherichia coli enzyme.