Journal ArticleDOI
Pharmacotherapeutic potential of omega-conotoxin MVIIA (SNX-111), an N-type neuronal calcium channel blocker found in the venom of Conus magus.
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This article is published in Toxicon.The article was published on 1998-11-01. It has received 116 citations till now. The article focuses on the topics: Conus magus & Omega-Conotoxins.read more
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Drug development from marine natural products
Tadeusz F. Molinski,Doralyn S. Dalisay,Sarah L. Lievens,Sarah L. Lievens,Jonel P. Saludes,Jonel P. Saludes +5 more
TL;DR: The history of drug discovery from marine natural products is reviewed, and by describing selected examples, the factors that contribute to new discoveries and the difficulties associated with translating marine-derived compounds into clinical trials are examined.
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The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential
TL;DR: This review describes how use-dependent blockers of the different isoforms could selectively block calcium channels in particular pathologies, such as nociceptive neurons in pain states or in epileptic brain circuits, and describes how selectivity for different subtypes of calcium channels may be achieved in the future.
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Ziconotide for treatment of severe chronic pain
TL;DR: An overview of the benefits and limitations of intrathecal ziconotide treatment is provided and potential future developments in this new drug class of selective N-type voltage-sensitive calcium-channel blockers are reviewed.
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Calcium-Permeable Ion Channels in Pain Signaling
Emmanuel Bourinet,Christophe Altier,Michael E. Hildebrand,Tuan Trang,Michael W. Salter,Gerald W. Zamponi +5 more
TL;DR: A broad overview of different calcium-permeable ion channels in the afferent pain pathway and their role in pain pathophysiology is provided.
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Mechanisms for Evolving Hypervariability: The Case of Conopeptides
TL;DR: The combination of a targeted mutator mechanism to generate high variability with the subsequent action of diversifying selection on highly expressed variants might explain both the hypervariability of conopeptides and the large number of unique sequences per species.
References
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An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat.
Sun Ho Kim,Jin Mo Chung +1 more
TL;DR: Results suggested that the surgical procedure in all 3 groups produced a long-lasting hyperalgesia to noxious heat and mechanical allodynia of the affected foot and there were behavioral signs of the presence of spontaneous pain in the affectedFoot.
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A new model of bilateral hemispheric ischemia in the unanesthetized rat.
W A Pulsinelli,J B Brierley +1 more
TL;DR: A new model of transient, bilateral hemispheric ischemia in the unanesthetized rat is described, with the ease of preparation of large numbers of animals, a high rate of predictable ischemic neuronal damage, a low incidence of seizures and the absence of anesthesia.
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Calcium channel diversity and neurotransmitter release : the omega -conotoxins and omega -agatoxins
TL;DR: The level of intracellular Ca regulates many cellular processes, including neurotransmitter and hormone secretion, the activity of ion channels and enzymes, cytoskeletal function, cell proliferation, and gene expression.
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Peptide neurotoxins from fish-hunting cone snails
Baldomero M. Olivera,William R. Gray,R Zeikus,J M McIntosh,J Varga,Jean Rivier,V de Santos,Lourdes J. Cruz +7 more
TL;DR: Five new omega-conotoxins that block presynaptic calcium channels are described, and the fact that they inhibit sequential steps in neuromuscular transmission suggests that their action is synergistic rather than additive.