Journal ArticleDOI
Phenanthrene synthesis by iron-catalyzed [4+2] benzannulation between alkyne and biaryl or 2-alkenylphenyl Grignard reagent.
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The [4+2] benzannulation reaction of internal or terminal alkynes with 2-biaryl, 2-heteroarylphenyl, or 2-alkenylphenyl Grignard reagents in the presence of Fe(acac)(3), 4,4'-di-tert-butyl-2,2'-bipyridyl, and 1,2-dichloro-2-methylpropane takes place at room temperature in 1Abstract:
The [4 + 2] benzannulation reaction of internal or terminal alkynes with 2-biaryl, 2-heteroarylphenyl, or 2-alkenylphenyl Grignard reagents in the presence of Fe(acac)3, 4,4′-di-tert-butyl-2,2′-bipyridyl, and 1,2-dichloro-2-methylpropane takes place at room temperature in 1 h to give 9-substituted or 9,10-disubstituted phenanthrenes and congeners in moderate to excellent yields. The reaction tolerates sensitive functional groups such as bromide and olefin. When applied to a 1,3-diyne, the annulation reaction takes place on both acetylenic moieties to give a bisphenanthrene derivative.read more
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3d Transition Metals for C-H Activation.
Parthasarathy Gandeepan,Thomas Müller,Daniel Zell,Gianpiero Cera,Svenja Warratz,Lutz Ackermann +5 more
TL;DR: A comprehensive overview on first row transition metal catalysts for C-H activation until summer 2018 is provided.
Journal ArticleDOI
Iron-Catalyzed C-H Bond Activation.
TL;DR: This review includes reactions that take place via reactive organoiron intermediates, and it covers the reactions of simple substrates and substrates possessing a directing group that anchors the catalyst to the substrate, providing an overview of iron-mediated and iron-catalyzed C-H activation reported in the literature by October 2016.
Journal ArticleDOI
Cu(II)-mediated C-H amidation and amination of arenes: exceptional compatibility with heterocycles.
TL;DR: A Cu(OAc)2-mediated C-H amidation and amination of arenes and heteroarenes has been developed using a readily removable directing group, making this a broadly applicable method for the synthesis of a family of inhibitors including 2-benzamidobenzoic acids and N-phenylaminobenzosates.
Journal ArticleDOI
Iron-catalyzed/mediated oxidative transformation of C–H bonds
Fan Jia,Zhiping Li +1 more
TL;DR: In this paper, the authors focus on C-H bond cleavage in oxidative transformation via iron catalysis, as well as applications in synthetic chemistry, and present a review of the state of the art at the frontiers of chemistry.
References
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Journal ArticleDOI
Iron-Catalyzed Reactions in Organic Synthesis
TL;DR: A new iron(III) halide-promoted aza-Prins cyclization between γ,δ-unsaturated tosylamines and aldehydes provides six-membered azacycles in good to excellent yields.
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Direct C-H transformation via iron catalysis.
Journal ArticleDOI
The Promise and Challenge of Iron-Catalyzed Cross Coupling
TL;DR: The preparative aspects of iron-catalyzed cross coupling are encouraging, but the inclination to classify these processes within the characteristic reaction manifold is premature, as mechanistic studies have evolved at a comparatively slow pace.
Journal ArticleDOI
Sustainable Metal Catalysis with Iron: From Rust to a Rising Star?
Journal ArticleDOI
The Chemistry of Organic Nanomaterials
Andrew C. Grimsdale,Klaus Müllen +1 more
TL;DR: This Review aims to show how the interaction between synthetic chemistry and spectroscopy has driven the field of organic nanomaterials forward towards the ultimate goal of new technology.
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