Journal ArticleDOI
Phosphodiesterase protein activator mimics red blood cell cytoplasmic activator of (Ca2+-Mg2+)ATPase.
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TLDR
Both phosphodiesterase activator and RBC cytoplasmic activator increase the Vmax and the apparent affinity of (Ca2-Mg2+)ATPase for Ca2+.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1977-08-22. It has received 462 citations till now. The article focuses on the topics: Activator (genetics) & Enzyme activator.read more
Citations
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Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
TL;DR: Both the holoenzyme and the catalytic subunit (or fragment), which is active without an enzyme activator, are susceptible to these compounds with a similar concentration dependency, thereby indicating that the inhibitory effect is attributed to the direct interaction of the compound with the active center of the enzyme but not with the enzymeactivator.
Journal ArticleDOI
Calmodulin plays a pivotal role in cellular regulation
TL;DR: The role of calcium ions (Ca2+) in cell function is beginning to be unraveled at the molecular level as a result of recent research on calcium-binding proteins and particularly on calmodulin.
Journal ArticleDOI
The role of protein phosphorylation in neural and hormonal control of cellular activity
TL;DR: There is an integrated network of regulatory pathways, mediated by phosphorylation–dephosphorylation, that allows diverse cellular events to be coordinated by neural and hormonal stimuli, and the evidence that supports this concept is reviewed.
Journal ArticleDOI
Calmodulin—an intracellular calcium receptor
Anthony R. Means,John R. Dedman +1 more
TL;DR: Calmodulin, a protein that binds calcium with high affinity and specificity, is structurally conserved and functionally preserved throughout the animal and plant kingdoms.
Journal ArticleDOI
Structure and evolution of calcium-modulated proteins.
TL;DR: The intracellular functions of calcium are best understood in terms of calcium's functioning as a second messenger, and this line of thought leads to a suggestion of the evolutionary reason for the choice of calcium as the sole inorganic second messenger.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes
TL;DR: The effects of the ionic strength and pH of the hemolyzing solution on the hemoglobin content of human erythrocyte ghosts were studied in phosphate buffers and suggest an electrophysical interaction of hemoglobin with membrane constituents.
Journal ArticleDOI
Calcium movements across the membrane of human red cells.
TL;DR: A study has been made of the cellular content and movement of Ca across the membrane of human red blood cells and the results show that Ca levels in the blood are low and Ca content is high inocytes.
Journal ArticleDOI
Cyclic 3',5'-nucleotide phosphodiesterase. Evidence for and properties of a protein activator.
TL;DR: It was concluded that the residual activity associated with the purified enzyme was due to an incomplete removal of the activator from the enzyme.
Related Papers (5)
Cyclic 3',5'-nucleotide phosphodiesterase. Demonstration of an activator.
W Y Cheung,W Y Cheung +1 more