Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics.
TLDR
The results suggest that enhanced PC flipping activity due to exogenous ATP10A expression alters the lipid composition at the plasma membrane, which may in turn cause a delay in cell spreading and a change in cell morphology.About:
This article is published in Journal of Biological Chemistry.The article was published on 2015-06-12 and is currently open access. It has received 68 citations till now. The article focuses on the topics: Phosphatidylserine & Flippase.read more
Citations
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Exposure of phosphatidylserine on the cell surface.
TL;DR: How PtdSer is exposed in apoptotic cells and in activated platelets is described and discussed, and Ptd Ser exposure in other biological processes is discussed.
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P4-ATPases as Phospholipid Flippases-Structure, Function, and Enigmas.
Jens Peter Andersen,Anna L. Vestergaard,Stine A. Mikkelsen,Louise S Mogensen,Madhavan Chalat,Robert S. Molday +5 more
TL;DR: The P4-ATPase mechanism is quite similar to the mechanism of these ion pumps, where the glutamate translocates the ions by moving like a pump rod, and most mechanistic insight is available.
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Lipid somersaults: Uncovering the mechanisms of protein-mediated lipid flipping
TL;DR: This work focuses on conceptual aspects, highlighting mechanistic insights from biochemical and in silico experiments, and the recent, ground-breaking identification of a number of lipid scramblases.
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Transbilayer lipid asymmetry
TL;DR: The plasma membrane is a ∼4 nm thick phospholipid bilayer that defines the boundary of a cell, segregating internal content from the external environment, and its hydrophobic interior presents a barrier to the exchange of ions and polar solutes between the inside and outside of the cell.
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Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium
TL;DR: By expressing 12 human type IV P-type ATPases in ATP11C-deficient cells, it is determined that ATP8A2 and ATP11A can also act as plasma membrane flippases.
References
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TL;DR: How do cells apply anabolic and catabolic enzymes, translocases and transporters, plus the intrinsic physical phase behaviour of lipids and their interactions with membrane proteins, to create the unique compositions and multiple functions of their individual membranes?
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Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells
TL;DR: This work has shown that the outer leaflet of eukaryotic plasma membranes is formed predominantly with the cholinephospholipids (sphingomyelin and phosphatidylcholine [PC], whereas the majority of the
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Lipid asymmetry in membranes
TL;DR: Three sections of this chapter describing various approaches to study membrane lipid asymmetry are written by three different groups.
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The distribution and function of phosphatidylserine in cellular membranes.
TL;DR: The determinants and functional implications of the subcellular distribution and membrane topology of the most abundant negatively charged phospholipid in eukaryotic membranes are discussed.
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ATP-dependent asymmetric distribution of spin-labeled phospholipids in the erythrocyte membrane: relation to shape changes
TL;DR: It is suggested that an ATP-driven transport of aminoospholipids toward the inner leaflet could be the major cause of the phospholipid asymmetry in the erythrocyte membrane.