Photoreceptor cell death and rescue in retinal detachment and degenerations.
Yusuke Murakami,Shoji Notomi,Shoji Notomi,Toshio Hisatomi,Toru Nakazawa,Tatsuro Ishibashi,Joan W. Miller,Demetrios G. Vavvas +7 more
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TLDR
A body of studies indicate that not only apoptotic but also autophagic and necrotic signaling are involved in photoreceptor cell death, and that combined targeting of these pathways may be an effective neuroprotective strategy for retinal diseases associated with photorecept cell loss.About:
This article is published in Progress in Retinal and Eye Research.The article was published on 2013-11-01 and is currently open access. It has received 175 citations till now. The article focuses on the topics: Photoreceptor cell & Retinal degeneration.read more
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Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases
Nicolás Cuenca,Laura Fernández-Sánchez,Laura Campello,Victoria Maneu,Pedro de la Villa,Pedro Lax,Isabel Pinilla +6 more
TL;DR: An overview of the common and distinctive features of retinal neurodegenerative diseases, including the molecular, anatomical and functional changes caused by the cellular response to damage, are provided in order to establish appropriate treatments for these pathologies.
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Molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspectives
Marina França Dias,Kwangsic Joo,Jessica A. Kemp,Sílvia Ligório Fialho,Armando da Silva Cunha,Se Joon Woo,Se Joon Woo,Young Jik Kwon +7 more
TL;DR: Development in gene editing technology and novel gene delivery carriers make gene therapy a promising therapeutic modality for RP and other hereditary retinal dystrophies in the future.
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Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical consequences.
J. Carlos Pastor,Jimena Rojas,Jimena Rojas,Salvador Pastor-Idoate,Salvador Pastor-Idoate,Salvatore Di Lauro,Lucia Gonzalez-Buendia,Santiago Delgado-Tirado +7 more
TL;DR: Inflammation is one of the major components of PVR, and new genetic biomarkers that have the potential to predict its development are described, including one directed towards neuroprotection, which can also be useful for preventing visual loss after any RD.
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Autophagy in the eye: Development, degeneration, and aging.
Patricia Boya,Lorena Esteban-Martínez,Ana Serrano-Puebla,Raquel Gómez-Sintes,Beatriz Villarejo-Zori +4 more
TL;DR: The role of autophagy in retinal development and cell differentiation is described, and the implications of Autophagy dysregulation both in physiological aging and in important diseases such as age-associated macular degeneration and glaucoma are discussed.
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Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps.
Jacque L. Duncan,Eric A. Pierce,Amy M. Laster,Stephen P. Daiger,David G. Birch,John D. Ash,Alessandro Iannaccone,John G. Flannery,Jose A. Sahel,Jose A. Sahel,Donald J. Zack,Marco A. Zarbin +11 more
TL;DR: This research presents a novel and scalable approach, called “Smart Gene Regulation,” which aims to provide real-time information about the activity of the immune cells in the eyes of the visually-impaired.
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Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
TL;DR: Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
TL;DR: The extent of tissue-PCD revealed by this method is considerably greater than apoptosis detected by nuclear morphology, and thus opens the way for a variety of studies.
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Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
Peng Li,Deepak Nijhawan,Imawati Budihardjo,Srinivasa M. Srinivasula,Manzoor Ahmad,Emad S. Alnemri,Xiaodong Wang +6 more
TL;DR: Mutation of the active site of caspase-9 attenuated the activation of cazase-3 and cellular apoptotic response in vivo, indicating that casp enzyme-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP.
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Autophagy fights disease through cellular self-digestion
TL;DR: Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health, and to play a role in cell death.
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Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
TL;DR: The results indicate that BID is a mediator of mitochondrial damage induced by Casp8, and coexpression of BclxL inhibits all the apoptotic changes induced by tBID.