Journal ArticleDOI
Physico-chemical considerations of titanium as a biomaterial.
TLDR
Titanium has low ion-formation tendency and low reactivity with macromolecules, accompanied by low toxicity in aqueous environments, and does not facilitate reactive oxygen radical generation during inflammatory conditions as observed in in-vitro experiments.About:
This article is published in Clinical Materials.The article was published on 1992-01-01. It has received 339 citations till now. The article focuses on the topics: Titanium oxide & Titanium.read more
Citations
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Journal ArticleDOI
Preparation of bioactive Ti and its alloys via simple chemical surface treatment.
TL;DR: The present chemical surface modification is expected to allow the use the bioactive Ti and its alloys as artificial bones even under load-bearing conditions.
Journal ArticleDOI
High surface energy enhances cell response to titanium substrate microstructure.
Ge Zhao,Zvi Schwartz,Marco Wieland,Frank Rupp,Jürgen Geis-Gerstorfer,David L. Cochran,Barbara D. Boyan +6 more
TL;DR: Osteoblasts grown on modified Ti surfaces exhibited a more differentiated phenotype characterized by increased alkaline phosphatase activity and osteocalcin and generated an osteogenic microenvironment through higher production of PGE2 and TGF-beta1 and 1alpha,25OH2D3 increased these effects in a manner that was synergistic with high surface energy.
Journal ArticleDOI
Review on titanium and titanium based alloys as biomaterials for orthopaedic applications.
Manmeet Kaur,Kulvir Singh +1 more
TL;DR: Various attempts to improve upon these properties like different processing routes, surface modifications have been inculcated in the paper to provide an insight into the extent of research and effort that has been put into developing a highly superior titanium orthopaedic implant.
Journal ArticleDOI
The role of hydrated silica, titania, and alumina in inducing apatite on implants.
TL;DR: Pure soluble silica prepared by a sol-gel method induced bone-like hydroxyapatite formation onto its surface when the silica was immersed in a simulated body fluid (SBF), whereas silica glass and quartz did not, which directly supports the hypothesis that hydrated silica plays an important role in biologically active hydroxyic acid formation on the surfaces of bioactive glasses and glass-ceramics, which leads to bone-bonding.
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Spontaneous Formation of Bonelike Apatite Layer on Chemically Treated Titanium Metals
TL;DR: The present study shows that even pure titanium metal and its alloys can bond to living bone, if their surfaces are pre-treated with alkali hydroxide solutions.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
Oxygen toxicity, oxygen radicals, transition metals and disease
Journal ArticleDOI
A 15-year study of osseointegrated implants in the treatment of the edentulous jaw
TL;DR: The clinical results achieved with bridges on osseointegrated fixtures fulfill and exceed the demands set by the 1978 Harvard Conference on successful dental implantation procedures.
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Surface modification of titanium, titanium alloys, and related materials for biomedical applications
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