Journal ArticleDOI
Physicochemical Characteristics and In Vivo Deposition of Liposome-encapsulated Tea Catechins by Topical and Intratumor Administrations
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TLDR
The isomers, (+)-catechin and (−)-epicatechin, showed different physicochemical properties in liposomes and for local deposition in the skin and tumor and the presence of gallic acid ester in the structure of EGCG significantly increased the tissue uptake of catechins.Abstract:
Tea polyphenols, including (+)-catechin, (−)-epicatechin, and (−)-epigallocatechin-3-gallate (EGCG), have been shown to possess potent antioxidant and anticancer activities. The aim of this study was to evaluate the possibility of using liposomes for the local delivery, including skin and tumor deposition, of these polyphenols. Liposomes containing egg phosphatidylcholine, cholesterol, or anionic species were prepared by a solvent evaporation method and then were subjected to a probe sonicator. The size, zeta potential and entrapment efficiency of these liposomal formulations were determined to provide correlations with results from a subsequent in vivo study. The release rate study showed that inclusion of an anionic species, such as deoxycholic acid (DA) or dicetyl phosphate (DP), increased the permeability of the lipid bilayers, leading to the rapid release of these formulations. No significant increase in skin deposition of catechins was observed after topical application of liposomes. On the other ha...read more
Citations
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Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective.
TL;DR: Novel drug delivery systems (NDDS) would also help in delivery of these antioxidants by oral route, as this route is of prime importance when antioxidants are intended for prophylactic purpose.
Journal ArticleDOI
Encapsulation of Natural Polyphenolic Compounds; a Review
Aude Munin,Florence Edwards-Levy +1 more
TL;DR: In this review, after a general presentation of the large chemical family of plant polyphenols and of their main chemical and biological properties, encapsulation processes applied to polyphenol encapsulation are classified into physical, physico-chemical, chemical methods, and other connected stabilization methods.
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Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer
Petras Juzenas,Wei Chen,Ya Ping Sun,Manuel A. N. Coelho,Roman Generalov,Natalia Generalova,Ingeborg Lie Christensen +6 more
TL;DR: The concept of using quantum dots and nanoparticles to yield electrons and radicals in photodynamic and radiation therapies as well their combination is reviewed in this article.
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Advanced Drug Delivery Systems of Curcumin for Cancer Chemoprevention
TL;DR: Drug delivery systems such as nanoparticles, liposomes, microemulsions, and polymeric implantable devices are emerging as one of the viable alternatives that have been shown to deliver therapeutic concentrations of various potent chemopreventives such as curcumin, ellagic acid, green tea polyphenols, and resveratrol into the systemic circulation.
Journal ArticleDOI
Enhancement of the transdermal delivery of catechins by liposomes incorporating anionic surfactants and ethanol.
TL;DR: The results suggested that the liposomal composition plays an important role in affecting the efficiency of transdermal catechin delivery.
References
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Journal ArticleDOI
Delivery of Novel Therapeutic Agents in Tumors: Physiological Barriers and Strategies
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Particle size of liposomes influences dermal delivery of substances into skin.
TL;DR: The results indicated that the CF penetration was inversely related to the size of the liposomes, which was confirmed by the data of the confocal laser scanning microscopy studies.
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The Carrier Potential of Liposomes in Biology and Medicine
TL;DR: (Second of Two Parts)
Journal Article
Absorption, distribution, elimination of tea polyphenols in rats.
TL;DR: The distribution results suggest that EGCG is mainly excreted through bile, and that E GC and EC are excreting through both the bile and urine.
Journal ArticleDOI
Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes.
TL;DR: Results indicate that only spleen homing liposomes can be used as a blocking reagent to prolong the circulation time of the large GM1-containing liposome circulation time in the blood.