Polarity and Specific Sequence Requirements of Peroxisome Proliferator-activated Receptor (PPAR)/Retinoid X Receptor Heterodimer Binding to DNA A FUNCTIONAL ANALYSIS OF THE MALIC ENZYME GENE PPAR RESPONSE ELEMENT
TLDR
It is demonstrated that only MEp and not MEd is able to bind PPAR/retinoid X receptor (RXR) heterodimers and mediate peroxisome proliferator signaling.About:
This article is published in Journal of Biological Chemistry.The article was published on 1997-08-08 and is currently open access. It has received 362 citations till now. The article focuses on the topics: Retinoid X receptor & Thyroid hormone receptor.read more
Citations
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Journal ArticleDOI
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
Béatrice Desvergne,Walter Wahli +1 more
TL;DR: This work has shown that direct expression of PPAR mRNAs in the absence of a specific carrier gene results in down-regulation in the activity of other PPARs, and these properties are consistent with those of a “spatially aggregating substance”.
Journal ArticleDOI
The Mechanisms of Action of PPARs
Joel P. Berger,David E. Moller +1 more
TL;DR: The current state of knowledge regarding the molecular mechanisms of PPAR action and the involvement of the PPARs in the etiology and treatment of several chronic diseases is presented.
Journal ArticleDOI
Peroxisome proliferator-activated receptor α target genes
TL;DR: In this article, the involvement of PPARalpha in peroxisomal and mitochondrial fatty acid oxidation, microsomal fatty acid hydroxylation, lipoprotein, bile and amino acid metabolism, glucose homeostasis, biotransformation, inflammation control, hepato-carcinogenesis and other pathways, through a detailed analysis of the different known or putative PPARα target genes.
Journal ArticleDOI
Peroxisome Proliferator-Activated Receptor Alpha Target Genes
TL;DR: An overview of the involvement of PPARα in lipid metabolism and other pathways through a detailed analysis of the different known or putative PPAR α target genes is presented.
Journal ArticleDOI
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors
Liliane Michalik,Johan Auwerx,Joel P. Berger,V. Krishna K. Chatterjee,Christopher K. Glass,Frank J. Gonzalez,Paul Grimaldi,Takashi Kadowaki,Mitchell A. Lazar,Stephen O'Rahilly,Colin N. A. Palmer,Jorge Plutzky,Janardan K. Reddy,Bruce M. Spiegelman,Bart Staels,Walter Wahli +15 more
TL;DR: The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of the nuclear hormone receptor superfamily as discussed by the authors, which share a high degree of structural homology with all members of the superfamily, particularly in the DNA-binding domain and ligand and cofactor binding domain.
References
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Book ChapterDOI
Rapid and efficient site-specific mutagenesis without phenotypic selection
Journal ArticleDOI
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
TL;DR: In this paper, an enhancer from the 5'-flanking region of the adipocyte P2 (aP2) gene that directs high-level adipocyte-specific gene expression in both cultured cells and transgenic mice was identified.
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Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
TL;DR: This work presents the expression patterns of the PPAR subtypes in the adult rat, determined by in situ hybridization using specific probes for PPAR-alpha, -beta and -gamma, and by immunohistochemistry using a polyclonal antibody that recognizes the three rat PPar subtypes.
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Convergence of 9- cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
TL;DR: The coupling of the peroxisome proliferator and retinoid signalling pathways is demonstrated and evidence for a physiological role for 9-cis retinoic acid in modulating lipid metabolism is provided.
Journal ArticleDOI
CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements
Bruno Luckow,Günther Schütz +1 more
TL;DR: In the promoterless construction pBLCAT3 eight unique restriction sites are suitable for insertion of different eukaryotic promoters at the 5' end of the CAT gene, enabling the excision of the intact fusion gene from the prokaryotic vector.
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Peroxisome proliferator-activated receptors: nuclear control of metabolism.
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