Journal ArticleDOI
Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: The 'red complex', a prototype polybacterial pathogenic consortium in periodontitis
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This article is published in Periodontology 2000.The article was published on 2005-06-01. It has received 851 citations till now. The article focuses on the topics: Tannerella forsythia & Treponema denticola.read more
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The keystone-pathogen hypothesis
TL;DR: Critical assessment of the available literature that supports the keystone-pathogen hypothesis holds that certain low-abundance microbial pathogens can orchestrate inflammatory disease by remodelling a normally benign microbiota into a dysbiotic one.
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The oral microbiota: dynamic communities and host interactions.
TL;DR: Current knowledge and emerging mechanisms governing oral polymicrobial synergy and dysbiosis that have both enhanced the understanding of pathogenic mechanisms and aided the design of innovative therapeutic approaches for oral diseases are discussed.
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Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology.
TL;DR: A new model of pathogenesis according to which periodontitis is initiated by a synergistic and dysbiotic microbial community rather than by select 'periopathogens', such as the 'red complex' is described.
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Mechanisms of Bone Resorption in Periodontitis
TL;DR: Th1-type T lymphocytes, B cell macrophages, and neutrophils promote bone loss through upregulated production of proinflammatory mediators and activation of the RANK-L expression pathways.
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Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
Natalia Wegner,Karin Lundberg,Andrew J Kinloch,Benjamin A Fisher,Vivianne Malmström,Marc Feldmann,Patrick J Venables +6 more
TL;DR: Rheumatoid arthritis (RA) is now clearly a true autoimmune disease with accumulating evidence of pathogenic disease‐specific autoimmunity to citrullinated proteins, and both smoking and Porphyromonas gingivalis are attractive etiological agents for further investigation into the gene/environment/autoimmunities triad of RA.
References
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Integrins: a family of cell surface receptors.
TL;DR: This brief review of sequence data from embryogenesis, thrombosis, and lymphocyte help and killing is summarized and attempts to clarify the relationships among the members of this family of cell surface receptors.
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Microbial complexes in subgingival plaque
TL;DR: The purpose of the present investigation was to attempt to define communities using data from large numbers of plaque samples and different clustering and ordination techniques, which related strikingly to clinical measures of periodontal disease particularly pocket depth and bleeding on probing.
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The biology of interleukin-6.
TL;DR: Human IL-6 (BSF2) was originally identified as a factor in the culture supernatants of mitogen or antigen-stimulated peripheral mononuclear cells, which induced immunoglobulin production in Epstein Barr virus transformed B-cell lines or in Staphylococcus aureus Cowan 1 stimulated normal B cells.
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Listeria pathogenesis and molecular virulence determinants.
José A. Vázquez-Boland,José A. Vázquez-Boland,Michael Kuhn,Patrick Berche,Trinad Chakraborty,Gustavo Domínguez-Bernal,Werner Goebel,Bruno Gonzalez-Zorn,Jürgen Wehland,Jürgen Kreft +9 more
TL;DR: The molecular determinants of Listeria virulence and their mechanism of action are described and the current knowledge on the pathophysiology of listeriosis and the cell biology and host cell responses to Listersia infection is summarized.
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Bacterial Diversity in Human Subgingival Plaque
Bruce J. Paster,Bruce J. Paster,Susan K. Boches,Jamie L. Galvin,Rebecca E. Ericson,C. N. Lau,Valerie A. Levanos,Ashish Sahasrabudhe,Floyd E. Dewhirst,Floyd E. Dewhirst +9 more
TL;DR: The purpose of this study was to determine the bacterial diversity in the human subgingival plaque by using culture-independent molecular methods as part of an ongoing effort to obtain full 16S rRNA sequences for all cultivable and not-yet-cultivated species of human oral bacteria.