Journal ArticleDOI
Posaconazole vs. Fluconazole or Itraconazole Prophylaxis in Patients with Neutropenia
Oliver A. Cornely,Johan Maertens,Drew J. Winston,John R. Perfect,Andrew J. Ullmann,Thomas J. Walsh,David Helfgott,Jerzy Holowiecki,Dick Stockelberg,Yeow Tee Goh,Mario Petrini,Cathy Hardalo,Ramachandran Suresh,David Angulo-Gonzalez +13 more
TLDR
In patients undergoing chemotherapy for acute myelogenous leukemia or the myelodysplastic syndrome, posaconazoles prevented invasive fungal infections more effectively than did either fluconazole or itraconazole and improved overall survival.Abstract:
Background Patients with neutropenia resulting from chemotherapy for acute myelogenous leukemia or the myelodysplastic syndrome are at high risk for difficult-to-treat and often fatal invasive fungal infections. Methods In this randomized, multicenter study involving evaluators who were unaware of treatment assignments, we compared the efficacy and safety of posaconazole with those of fluconazole or itraconazole as prophylaxis for patients with prolonged neutropenia. Patients received prophylaxis with each cycle of chemotherapy until recovery from neutropenia and complete remission, until occurrence of an invasive fungal infection, or for up to 12 weeks, whichever came first. We compared the incidence of proven or probable invasive fungal infections during treatment (the primary end point) between the posaconazole and fluconazole or itraconazole groups; death from any cause and time to death were secondary end points. Results A total of 304 patients were randomly assigned to receive posaconazole, and 298 ...read more
Citations
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Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
Ben E. De Pauw,Thomas J. Walsh,J. Peter Donnelly,David A. Stevens,John E. Edwards,Thierry Calandra,Peter G. Pappas,Johan Maertens,Olivier Lortholary,Carol A. Kauffman,David W. Denning,Thomas F. Patterson,Georg Maschmeyer,Jacques Bille,William E. Dismukes,Raoul Herbrecht,William W. Hope,Christopher C. Kibbler,Bart Jan Kullberg,Kieren A. Marr,Patricia Muñoz,Frank C. Odds,John R. Perfect,Angela Restrepo,Markus Ruhnke,Brahm H. Segal,Jack D. Sobel,Tania C. Sorrell,Claudio Viscoli,John R. Wingard,Theoklis E. Zaoutis,John E. Bennett +31 more
TL;DR: These revised definitions of invasive fungal disease are intended to advance clinical and epidemiological research and may serve as a useful model for defining other infections in high-risk patients.
Journal ArticleDOI
Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America.
Peter G. Pappas,Carol A. Kauffman,David R. Andes,Daniel K. Benjamin,Thierry Calandra,John E. Edwards,Scott G. Filler,John F. Fisher,Bart Jan Kullberg,Luis Ostrosky-Zeichner,Annette C. Reboli,John H. Rex,Thomas J. Walsh,Jack D. Sobel +13 more
TL;DR: These updated guidelines replace the previous guidelines published in the 15 January 2004 issue of Clinical Infectious Diseases and are intended for use by health care providers who care for patients who either have or are at risk of these infections.
Journal ArticleDOI
Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet.
Hartmut Döhner,Elihu H. Estey,Sergio Amadori,Frederick R. Appelbaum,Thomas Büchner,Alan Kenneth Burnett,Hervé Dombret,Pierre Fenaux,David Grimwade,Richard A. Larson,Francesco Lo-Coco,Tomoki Naoe,Dietger Niederwieser,Gert J. Ossenkoppele,Miguel A. Sanz,Jorge Sierra,Martin S. Tallman,Bob Löwenberg,Clara D. Bloomfield +18 more
TL;DR: An international expert panel is provided to provide updated evidence- and expert opinion-based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials.
Journal ArticleDOI
Clinical Practice Guideline for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer: 2010 Update by the Infectious Diseases Society of America
Alison G. Freifeld,Eric J. Bow,Kent A. Sepkowitz,Michael Boeckh,James I. Ito,Craig A. Mullen,Issam I Raad,Kenneth V. I. Rolston,Jo Anne H. Young,John R. Wingard,Fred Hutchinson +10 more
TL;DR: This document updates and expands the initial Infectious Diseases Society of America (IDSA) Fever and Neutropenia Guideline that was published in 1997 and first updated in 2002 and developed a clearer definition of which populations of patients with cancer may benefit most from antibiotic, antifungal, and antiviral prophylaxis.
Journal ArticleDOI
Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America
Thomas J. Walsh,Elias Anaissie,David W. Denning,Raoul Herbrecht,Dimitrios P. Kontoyiannis,Kieren A. Marr,Vicki A. Morrison,Vicki A. Morrison,Brahm H. Segal,William J. Steinbach,David A. Stevens,David A. Stevens,Jo Anne H. Van Burik,John R. Wingard,Thomas F. Patterson +14 more
TL;DR: This research presents a novel, scalable, scalable and scalable approach that allows for real-time evaluation of the impact of Epstein-Barr virus on the development and management of childhood cancer in rats.
References
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Journal ArticleDOI
Epidemiology and Outcome of Zygomycosis: A Review of 929 Reported Cases
Maureen Roden,Theoklis E. Zaoutis,Wendy Buchanan,Tena A. Knudsen,Tatyana A. Sarkisova,Robert L. Schaufele,Michael Sein,Tin Sein,Christine C. Chiou,Jaclyn H. Chu,Dimitrios P. Kontoyiannis,Thomas J. Walsh +11 more
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Defining Opportunistic Invasive Fungal Infections in Immunocompromised Patients with Cancer and Hematopoietic Stem Cell Transplants: An International Consensus
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The number needed to treat: a clinically useful measure of treatment effect.
Richard J. Cook,David L. Sackett +1 more
TL;DR: The relative benefit of an active treatment over a control is usually expressed as the relative risk, the Relative risk reduction, or the odds ratio, but for clinical decision making, it is more meaningful to use the measure "number needed to treat."
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Aspergillosis case-fatality rate: systematic review of the literature.
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Journal ArticleDOI
A Controlled Trial of Fluconazole to Prevent Fungal Infections in Patients Undergoing Bone Marrow Transplantation
Jesse L. Goodman,Drew J. Winston,Ronald A. Greenfield,Pranatharthi H. Chandrasekar,Barry C. Fox,Herbert Kaizer,Richard K. Shadduck,Thomas C. Shea,Patrick J. Stiff,David J. Friedman,William G. Powderly,Jeffrey L. Silber,Harold W. Horowitz,Alan E. Lichtin,Steven N. Wolff,Mangan Kf,Samuel M. Silver,Daniel J. Weisdorf,Winston G. Ho,Gene S. Gilbert,Donald N. Buell +20 more
TL;DR: Prophylactic administration of fluconazole to recipients of bone marrow transplants reduces the incidence of both systemic and superficial fungal infections.
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