Journal ArticleDOI
Positive effects of captopril in the behavioral despair swim test.
TLDR
The blockade of the captopril effects by naloxone suggests that brain opioid peptides play a role in this behavioral effect ofcaptopril, and the conclusion is guarded, as the positive effects may be related to motor stimulation.About:
This article is published in Biological Psychiatry.The article was published on 1989-03-15. It has received 60 citations till now. The article focuses on the topics: Captopril & Angiotensin II.read more
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Neuroendocrine and cytokine profile of chronic mild stress-induced anhedonia
TL;DR: The hypothesis that exposure to chronic mild stress (CMS), an experimental model of depression that induces anhedonia in rats, is sufficient to activate the production of proinflammatory cytokines and stress hormones that are detrimental to the heart and vascular system is examined.
Journal ArticleDOI
Brain renin-angiotensin--a new look at an old system.
John W. Wright,Joseph W. Harding +1 more
TL;DR: Current research efforts directed at the use of angiotensin analogues in the treatment of clinical disorders such as memory dysfunction, cerebral blood flow and cerebroprotection, stress, depression, alcohol consumption, seizure, Alzheimer's and Parkinson's diseases, and diabetes are summarized.
Journal ArticleDOI
The role of angiotensin II in cognition and behaviour.
TL;DR: Evidence concerning the role of the renin-angiotensin system in learning and memory is contradictory, although more studies support the proposal that ang Elliotensin reduces cognitive function.
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Angiotensin receptor subtype mediated physiologies and behaviors: new discoveries and clinical targets.
TL;DR: The renin-angiotensin system mediates several classic physiologies including body water and electrolyte homeostasis, blood pressure, cyclicity of reproductive hormones and sexual behaviors, and the regulation of pituitary gland hormones.
Journal ArticleDOI
Angiotensin as a target for the treatment of Alzheimer's disease, anxiety and depression
TL;DR: These findings suggest that angiotensin receptor ligands may have potential in the prevention or even reversal of vascular dementias and AD and the use of such agents in the treatment of hypertension coexisting with depression or anxiety.
References
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Journal Article
Behavioral despair in mice: a primary screening test for antidepressants
Porsolt Rd,Bertin A,Jalfre M +2 more
TL;DR: The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments.
Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
Journal ArticleDOI
The validity of animal models of depression.
TL;DR: The models with the highest overall validity are the intracranial self-stimulation, chronic stress and learned helplessness models in rats, and the primate separation model.
Journal ArticleDOI
The Effects of Antihypertensive Therapy on the Quality of Life
S H Croog,Sol Levine,Marcia A. Testa,Brown B,Bulpitt Cj,Jenkins Cd,Klerman Gl,Gordon H. Williams +7 more
TL;DR: It is shown that antihypertensive agents have different effects on the quality of life and that these can be meaningfully assessed with available psychosocial measures.
Journal ArticleDOI
The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice
Bernard P. Roques,Marie-Claude Fournie-Zaluski,E. Soroca,J.M. Lecomte,Bernard Malfroy,C. Llorens,J C Schwartz +6 more
TL;DR: Thiorphan is reported here that this compound, thiorphan [(DL-3-mercapto-2-benzylpropanoyl)-glycine; patent no. 8008601] protects the enkephalins from the action of enkephalinase in vitro in nanomolar concentration and in vivo after either intracerebroventricular or systemic administration.