Potential Roles of Stevia rebaudiana Bertoni in Abrogating Insulin Resistance and Diabetes: A Review
Nabilatul Hani Mohd-Radzman,Wan Iryani Wan Ismail,Zainah Adam,Siti Safura Jaapar,Aishah Adam +4 more
TLDR
In this paper, a review of mechanisms involving free fatty acids, adipocytokines such as TNFα and PPARγ and serine kinases like JNK and IKKβ, asserted to be responsible in the development of insulin resistance, are discussed.Abstract:
Insulin resistance is a key factor in metabolic disorders like hyperglycemia and hyperinsulinemia, which are promoted by obesity and may later lead to Type II diabetes mellitus. In recent years, researchers have identified links between insulin resistance and many noncommunicable illnesses other than diabetes. Hence, studying insulin resistance is of particular importance in unravelling the pathways employed by such diseases. In this review, mechanisms involving free fatty acids, adipocytokines such as TNFα and PPARγ and serine kinases like JNK and IKKβ, asserted to be responsible in the development of insulin resistance, will be discussed. Suggested mechanisms for actions in normal and disrupted states were also visualised in several manually constructed diagrams to capture an overall view of the insulin-signalling pathway and its related components. The underlying constituents of medicinal significance found in the Stevia rebaudiana Bertoni plant (among other plants that potentiate antihyperglycemic activities) were explored in further depth. Understanding these factors and their mechanisms may be essential for comprehending the progression of insulin resistance towards the development of diabetes mellitus.read more
Citations
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Stevia rebaudiana - přírodní nekalorické sladidlo
TL;DR: Stevie (Stevia rebaudiana) as mentioned in this paper is an Indian woman who has a history with diabetics in South America. But she is not a diabetic patient.
Journal ArticleDOI
Effect of stevia and pectin supplementation on physicochemical properties, preservation and in‐vivo hypoglycemic potential of orange nectar
Proceedings ArticleDOI
Factors Influence GLUT-4 Levels of Type 2 Diabetes Mellitus Patients in Medan City, Indonesia
Rina Amelia,Novita Sari Harahap +1 more
TL;DR: By increasing physical activity, proper nutrition management and weight control will help improve insulin sensitivity so that it can control blood sugar levels in T2DM patients.
Journal ArticleDOI
Biological activities of novel in vitro raised stevia plant
TL;DR: The vast potential of the lead fraction from methanolic extract of novel Stevia species raised under in vitro conditions for further development into a herbal formulation for prevention of various infectious and non-infectious diseases is signifies.
References
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