Potential Roles of Stevia rebaudiana Bertoni in Abrogating Insulin Resistance and Diabetes: A Review
Nabilatul Hani Mohd-Radzman,Wan Iryani Wan Ismail,Zainah Adam,Siti Safura Jaapar,Aishah Adam +4 more
TLDR
In this paper, a review of mechanisms involving free fatty acids, adipocytokines such as TNFα and PPARγ and serine kinases like JNK and IKKβ, asserted to be responsible in the development of insulin resistance, are discussed.Abstract:
Insulin resistance is a key factor in metabolic disorders like hyperglycemia and hyperinsulinemia, which are promoted by obesity and may later lead to Type II diabetes mellitus. In recent years, researchers have identified links between insulin resistance and many noncommunicable illnesses other than diabetes. Hence, studying insulin resistance is of particular importance in unravelling the pathways employed by such diseases. In this review, mechanisms involving free fatty acids, adipocytokines such as TNFα and PPARγ and serine kinases like JNK and IKKβ, asserted to be responsible in the development of insulin resistance, will be discussed. Suggested mechanisms for actions in normal and disrupted states were also visualised in several manually constructed diagrams to capture an overall view of the insulin-signalling pathway and its related components. The underlying constituents of medicinal significance found in the Stevia rebaudiana Bertoni plant (among other plants that potentiate antihyperglycemic activities) were explored in further depth. Understanding these factors and their mechanisms may be essential for comprehending the progression of insulin resistance towards the development of diabetes mellitus.read more
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Stevia rebaudiana targeting α-amylase: An in-vitro and in-silico mechanistic study
TL;DR: This study suggests that S. rebaudiana could be used in the development of therapeutic drugs for the treatment of diabetes by showing highest α-amylase inhibitory activity as compared to other extracts.
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Exploring Phytotherapeutic Alternatives for Obesity, Insulin Resistance and Diabetes Mellitus
Mervin Chávez-Castillo,Victoria Núñez,Milagros Rojas,Ángel Ortega,Pablo Duran,Daniela Pirela,María Marquina,Clímaco Cano,Maricarmen Chacín,Manuel Velasco,Joselyn Rojas-Quintero,Valmore Bermúdez +11 more
TL;DR: This review comprises an exploration of currently available preclinical and clinical research on the role of MH in the management of obesity, IR, and DM.
Journal ArticleDOI
Pharmacokinetic study of HS061, a new human insulin, in non-diabetic rat using ultra performance liquid chromatography–tandem mass spectrometry
TL;DR: A simple and accurate UPLC-MS/MS method was developed for the pharmacokinetic studies of HS061 in non-diabetic rats followed by a full method validation, and maximum plasma concentration and area under the curve for the subcutaneous doses of HS 061 was approximately dose proportional while other pharmacokinetics parameters showed no significant differences among the three doses.
Natural resources with sweetener power: phytochemistry and antioxidant characterisation of Stevia Rebaudiana (Bert.), sensorial and centesimal analyses of lemon cake recipes with S. Rebaudiana incorporation
Carla Sousa e Silva,Adriana Oliveira,Sara Vanessa Pinto,M. Conceição Manso,Ana Ferreira da Vinha +4 more
TL;DR: The hydroalcoholic extract of dried Stevia rebaudiana leaves showed high in vitro antioxidant activity, besides a positive correlation between total phenolic compounds and the DPPH and FRAP assays, and is likely to become a major source of natural sweetener for the growing food market.
Journal ArticleDOI
Development of cereal bars with adequate nutritional profile for each trimester of pregnancy– An exploratory study: Desenvolvimento de barritas de cereais com perfil nutricional adequado a cada trimestre da gravidez – Um estudo exploratório
TL;DR: In this article, three cereal bars with a common base were obtained, to which were added nutritionally adequate ingredients for the nutritional needs of each respective trimester for pregnant women without known nutritional deficiency or pathology.
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