Potential use of gene drive modified insects against disease vectors, agricultural pests and invasive species poses new challenges for risk assessment.
Yann Devos,John D. Mumford,Michael B. Bonsall,Ana M Camargo,Leslie George Firbank,Debora C.M. Glandorf,Fabien Nogué,Konstantinos Paraskevopoulos,Ernst A. Wimmer +8 more
TLDR
In this article, the potential future development of new or additional risk assessment guidance for engineered gene drives (GDs) modified insects is discussed, as well as the areas where further risk assessment may be required.Abstract:
Potential future application of engineered gene drives (GDs), which bias their own inheritance and can spread genetic modifications in wild target populations, has sparked both enthusiasm and concern. Engineered GDs in insects could potentially be used to address long-standing challenges in control of disease vectors, agricultural pests and invasive species, or help to rescue endangered species, and thus provide important public benefits. However, there are concerns that the deliberate environmental release of GD modified insects may pose different or new harms to animal and human health and the wider environment, and raise novel challenges for risk assessment. Risk assessors, risk managers, developers, potential applicants and other stakeholders at many levels are currently discussing whether there is a need to develop new or additional risk assessment guidance for the environmental release of GD modified organisms, including insects. Developing new or additional guidance that is useful and practical is a challenge, especially at an international level, as risk assessors, risk managers and many other stakeholders have different, often contrasting, opinions and perspectives toward the environmental release of GD modified organisms, and on the adequacy of current risk assessment frameworks for such organisms. Here, we offer recommendations to overcome some of the challenges associated with the potential future development of new or additional risk assessment guidance for GD modified insects and provide considerations on areas where further risk assessment guidance may be required.read more
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Risk management recommendations for environmental releases of gene drive modified insects.
Yann Devos,Yann Devos,John D. Mumford,Michael B. Bonsall,Debora C.M. Glandorf,Hector Quemada +5 more
TL;DR: In this article, the authors provide recommendations that may help to improve the relevance of risk assessment and risk management frameworks for environmental releases of gene drive modified insects (GDMIs) by developing additional and more practical risk assessment guidance to ensure appropriate levels of safety.
Journal ArticleDOI
Risk management recommendations for environmental releases of gene drive modified insects
TL;DR: In this paper , the authors provide recommendations that may help to improve the relevance of risk assessment and risk management frameworks for environmental releases of gene drive modified insects (GDMIs) by developing additional and more practical risk assessment guidance to ensure appropriate levels of safety.
Journal ArticleDOI
Recommendations for environmental risk assessment of gene drive applications for malaria vector control
John B. Connolly,John D. Mumford,Debora C. M. Glandorf,Sarah Hartley,Owen T. Lewis,Sam Weiss Evans,Geoff Turner,Camilla Beech,Naima Sykes,Mamadou B. Coulibaly,Jörg Romeis,John L. Teem,Willy K. Tonui,Brian Lovett,Aditi Mankad,Abraham Mnzava,Silke Fuchs,Talya D. Hackett,Wayne G. Landis,John M. Marshall,Fred Aboagye-Antwi +20 more
TL;DR: In this article , a series of online workshops identified nine recommendations to advance future environmental risk assessment of gene drive applications, based on an exercise that identified potential harms from simulated investigational releases of a population suppression gene drive for malaria vector control.
Journal ArticleDOI
Recommendations for environmental risk assessment of gene drive applications for malaria vector control
John B. Connolly,John D. Mumford,Debora C. M. Glandorf,Sarah Hartley,Owen T. Lewis,Sam Weiss Evans,Geoff Turner,Camilla Beech,Naima Sykes,Mamadou B. Coulibaly,Jörg Romeis,John L. Teem,Willy Tonui,Brian Lovett,Aditi Mankad,Abraham Mnzava,Silke Fuchs,Talya D. Hackett,Wayne G. Landis,John M. Marshall,Fred Aboagye-Antwi +20 more
TL;DR: In this article , a series of online workshops identified nine recommendations to advance future environmental risk assessment of gene drive applications, based on an exercise that identified potential harms from simulated investigational releases of a population suppression gene drive for malaria vector control.
Journal ArticleDOI
Gene drive in species complexes: defining target organisms.
John B. Connolly,Jörg Romeis,Yann Devos,Debora C. M. Glandorf,Geoff Turner,Mamadou B. Coulibaly +5 more
TL;DR: In this paper , the authors incorporate the concept of target species complexes, which offers more flexibility when assessing potential impacts from vertical gene drive transfer (VGDT) to sibling species biologically plausible.
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