Predictive validity of a non-induced mouse model of compulsive-like behavior
D. M. Greene-Schloesser,van der Eddy Zee,D. K. Sheppard,M. R. Castillo,Kelsey A. Gregg,T. Burrow,H. Foltz,M. Slater,Abel Bult-Ito +8 more
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TLDR
Together, the results indicate that these mice have good face and predictive validity as a non-induced mouse model of compulsive-like behavior relevant to OCD.About:
This article is published in Behavioural Brain Research.The article was published on 2011-08-01 and is currently open access. It has received 63 citations till now. The article focuses on the topics: House mice & Deer mouse.read more
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Burrowing and nest building behavior as indicators of well-being in mice.
TL;DR: In combination with specific disease markers, changes in nest building and burrowing performance may help provide a global picture of a mouse's state, and thus aid monitoring to ensure well-being in animal experimentation.
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A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: Mapping the way forward
TL;DR: The present review concludes by underlining that the collective translational value of the MBT will be strengthened by contextually valid experimental designs and objective reporting of data.
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Bisphenol S (BPS) Alters Maternal Behavior and Brain in Mice Exposed During Pregnancy/Lactation and Their Daughters.
TL;DR: It is demonstrated that pregnancy and lactation are vulnerable periods for the mother and that developmental BPS exposure alters maternal behavior later in adulthood, and both findings have potential public health implications.
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Current animal models of obsessive compulsive disorder: an update.
Noa Albelda,Daphna Joel +1 more
TL;DR: An overview of the currently active animal models of obsessive compulsive disorder, their strengths and limitations are provided, so that the reader can use the review as a guide for establishing newAnimal models of OCD, evaluating existing animal models and choosing among them according to one's needs.
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Essential role for orbitofrontal serotonin 1B receptors in obsessive-compulsive disorder-like behavior and serotonin reuptake inhibitor response in mice.
TL;DR: It is indicated that orbitof prefrontal 5-HT1BRs are necessary and sufficient to induce OCD-like behavior in mice and that SRI pharmacotherapy reduces OCD- like behavior by desensitizing orbitofrontal 5- HT1 BRs.
References
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Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat.
TL;DR: A novel test for the selective identification of anxiolytic and anxiogenic drug effects in the rat is described, using an elevated + -maze consisting of two open arms and two enclosed arms, which showed that behaviour on the maze was not clearly correlated either with exploratory head-dipping or spontaneous locomotor activity.
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A review and meta-analysis of the genetic epidemiology of anxiety disorders.
TL;DR: Meta-analyses of data from family and twin studies of panic disorder, generalized anxiety disorder, phobias, and obsessive-compulsive disorder revealed significant familial aggregation, underscoring the importance of identifying putative environmental risk factors that predispose individuals to anxiety.
Book
Obsessive Compulsive Disorder
TL;DR: A large number of patients with OCD are diagnosed with at least some form of obsessive-compulsive disorder, which is still probably the least understood of all the major psychiatric syndromes.