Predictors and outcomes of stent thrombosis. An intravascular ultrasound registry
Neal G. Uren,Severin P. Schwarzacher,Jonas A. Metz,David P. Lee,Yasuhiro Honda,Alan C. Yeung,Peter J. Fitzgerald,Paul G. Yock +7 more
TLDR
On comparison with angiography, the vast majority of stents associated with subsequent thrombosis have at least one abnormal feature by intravascular ultrasound at the time of stent deployment.Abstract:
Aims To investigate whether intravascular ultrasound provides additional information regarding the prediction of stent thrombosis, a retrospective multicentre registry was designed to enrol patients with stent thrombosis following stent deployment under ultrasound guidance.
Methods and Results A total of 53 patients were enrolled (mean age 61±9 years) with stable angina (43%), unstable angina (36%), and post-infarct angina (21%) who underwent intracoronary stenting. The majority had balloon angioplasty alone prior to stenting (94%) with 6% also undergoing rotational atherectomy. The indication for stenting was elective (53%), suboptimal result (32%) and bailout (15%). There were 1·6±0·8 stents/artery with 87% undergoing high-pressure dilatation (≥14 atmospheres). The minimum stent area was 7·7±2·8mm2with a mean stent expansion of 81·5±21·9%. Overall, 94% of cases demonstrated one abnormal ultrasound finding (stent under-expansion, malapposition, inflow/outflow disease, dissection, or thrombus). Angiography demonstrated an abnormality in only 32% of cases (chi-square=30·0, P <0·001). Stent thrombosis occurred at 132±125h after deployment. Myocardial infarction occurred in 67% and there was an overall mortality of 15%.
Conclusion On comparison with angiography, the vast majority of stents associated with subsequent thrombosis have at least one abnormal feature by intravascular ultrasound at the time of stent deployment.read more
Citations
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Incomplete Stent Apposition and Very Late Stent Thrombosis After Drug-Eluting Stent Implantation
Stéphane Cook,Peter Wenaweser,Mario Togni,Michael Billinger,Cyrill Morger,Christian Seiler,Rolf Vogel,Otto M. Hess,Bernhard Meier,Stephan Windecker +9 more
TL;DR: Incomplete stent apposition is highly prevalent in patients with very late stent thrombosis after DES implantation, suggesting a role in the pathogenesis of this adverse event.
Journal ArticleDOI
Stent underexpansion and residual reference segment stenosis are related to stent thrombosis after sirolimus-eluting stent implantation: An intravascular ultrasound study
Kenichi Fujii,Stephane Carlier,Gary S. Mintz,Yi-ming Yang,Issam Moussa,Giora Weisz,George Dangas,Roxana Mehran,Alexandra J. Lansky,Edward M. Kreps,Michael B. Collins,Gregg W. Stone,Jeffrey W. Moses,Martin B. Leon +13 more
TL;DR: In this article, the predictors of stent thrombosis after sirolimus-eluting stent (SES) implantation were determined. But, their results were limited to 15 patients who developed STC after successful SES implantation.
Journal ArticleDOI
Predictors of coronary stent thrombosis: the Dutch Stent Thrombosis Registry.
Jochem W. van Werkum,A. A. C. M. Heestermans,A. Carla Zomer,Johannes C. Kelder,M. J. Suttorp,Benno J. Rensing,Jacques J. Koolen,B. R. Guus Brueren,Jan-Henk E. Dambrink,Raymond W. Hautvast,Freek W.A. Verheugt,Jurriën M. ten Berg +11 more
TL;DR: Discontinuation of clopidogrel, undersizing of the coronary stent, present malignancy, and intermediate coronary artery disease proximal to the culprit lesion were the strongest predictors of stent thrombosis.
Journal ArticleDOI
Coronary stents: current status.
Scot Garg,Patrick W. Serruys +1 more
TL;DR: The benefits, risks, and current status of Food and Drug Administration-approved drug-eluting stents are reviewed.
Journal ArticleDOI
Angiographic Stent Thrombosis After Routine Use of Drug-Eluting Stents in ST-Segment Elevation Myocardial Infarction: The Importance of Thrombus Burden
Georgios Sianos,Michail I. Papafaklis,Joost Daemen,Sofia Vaina,Carlos Van Mieghem,Ron T. van Domburg,Lampros K. Michalis,Patrick W. Serruys +7 more
TL;DR: Large thrombus burden is an independent predictor of MACE and IRA-ST in patients treated with drug-eluting stent (DES) implantation for ST-segment elevation myocardial infarction (STEMI).
References
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Marco A. Costa,Manel Sabaté,Wim J. van der Giessen,I. Patrick Kay,Pavel Cervinka,Jurgen Ligthart,P. Serrano,V.L.M.A. Coen,Peter C. Levendag,Patrick W. Serruys +9 more
TL;DR: Late and sudden thrombosis after PTCA followed by intracoronary radiotherapy is a new phenomenon in interventional cardiology and the effect of radiation on delaying the healing process and maintaining aThrombogenic coronary surface is proposed as the most plausible mechanism to explain such late events.