Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study.
Rong Hui Du,Li Rong Liang,Cheng Qing Yang,Wen Wang,Tan Ze Cao,Ming Li,Guang Yun Guo,Juan Du,Chun Lan Zheng,Qi Zhu,Ming Hu,Xu Yan Li,Peng Peng,Huan-Zhong Shi +13 more
TLDR
Age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1 were four risk factors predicting high mortality of COVID-19 pneumonia patients.Abstract:
The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2. All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression was performed to investigate the relationship between each variable and the risk of death of COVID-19 pneumonia patients. In total, 179 patients with COVID-19 pneumonia (97 male and 82 female) were included in the present prospective study, of whom 21 died. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.146‒17.394; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 0.755‒8.044; p=0.007), CD3+CD8+ T-cells ≤75 cells·μL−1 (OR 3.982, 95% CI 1.132‒14.006; p We identified four risk factors: age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1. The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients.read more
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Mycobacterium tuberculosis and SARS-CoV-2 Coinfections: A Review
Narjess Bostanghadiri,Faramarz Masjedian Jazi,Shabnam Razavi,Lanfranco Fattorini,Davood Darban-Sarokhalil +4 more
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Armando Coca,Carla Burballa,Francisco Javier Centellas-Pérez,María José Pérez-Sáez,Elena Bustamante-Munguira,Agustín Ortega,Carlos Dueñas,María Dolores Arenas,Juan Pérez-Martínez,Guadalupe Ruiz,Marta Crespo,Llamas F,Juan Bustamante-Munguira,Julio Pascual +13 more
TL;DR: CKD patients that require hospitalization due to COVID-19 are exposed to higher risk of death and AKI, and patients with AKI had the highest hazard for death.
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TL;DR: In this paper, a review aims at highlighting some of the developments in lung neutrophil-immunity by focusing on the functions and roles of CXC/CC chemokines and pattern recognition receptors during pulmonary inflammations.
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Point-specific interactions of isovitexin with the neighboring amino acid residues of the hACE2 receptor as a targeted therapeutic agent in suppressing the SARS-CoV-2 influx mechanism
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TL;DR: Isovitexin is a phytochemical with a reasonable bioactivity and safety profile for use in humans, and it can potentially be used as a hACE2-specific therapeutic to inhibit COVID-19 infection.
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Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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