Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study.
Rong Hui Du,Li Rong Liang,Cheng Qing Yang,Wen Wang,Tan Ze Cao,Ming Li,Guang Yun Guo,Juan Du,Chun Lan Zheng,Qi Zhu,Ming Hu,Xu Yan Li,Peng Peng,Huan-Zhong Shi +13 more
TLDR
Age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1 were four risk factors predicting high mortality of COVID-19 pneumonia patients.Abstract:
The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2. All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression was performed to investigate the relationship between each variable and the risk of death of COVID-19 pneumonia patients. In total, 179 patients with COVID-19 pneumonia (97 male and 82 female) were included in the present prospective study, of whom 21 died. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.146‒17.394; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 0.755‒8.044; p=0.007), CD3+CD8+ T-cells ≤75 cells·μL−1 (OR 3.982, 95% CI 1.132‒14.006; p We identified four risk factors: age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1. The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients.read more
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Early mortality after hip fracture surgery in COVID-19 patients: A systematic review and meta-analysis.
TL;DR: It is demonstrated that COVID-19 infection represents a substantial risk factor for early postoperative mortality in the already susceptible hip fracture population and further investigations will be needed to assess longer-term morbidity and mortality in this patient population.
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The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study.
Dengfeng Gao,Min Xu,Gang Wang,Jianrui Lv,Xiao-Rong Ma,Yonghong Guo,Dexin Zhang,Huiyun Yang,Wei Jiang,Fuxue Deng,Guozhi Xia,Ziwei Lu,Lv Lv,Shouping Gong +13 more
TL;DR: In this article, the authors evaluated the efficacy and safety of high-dose vitamin C in patients with Coronavirus disease 2019 and found that the risk of 28-day mortality was reduced for the high dose versus the standard therapy group (HR=0.14, 95% CI, 0.03-0.72).
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Diabetes Mellitus is Associated with Severe Infection and Mortality in Patients with COVID-19: A Systematic Review and Meta-analysis.
TL;DR: DM is associated with increased risk of severe infection and higher mortality in patients with COVID-19, and clinicians should pay more attention to the monitoring and treatment of patients with DM.
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Special features of SARS-CoV-2 in daily practice
Ioannis Alexandros Charitos,Andrea Ballini,Lucrezia Bottalico,Stefania Cantore,Pier Carmine Passarelli,Francesco Inchingolo,Antonio D'Addona,Luigi Santacroce +7 more
TL;DR: Current medical knowledge and research on severe and critical patients’ management and experimental treatments are still evolving, but several protocols on minimizing risk of infection among the general population, patients and healthcare workers have been approved and diffused by International Health Authorities.
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Risk factors for mortality of coronavirus disease-2019 (COVID-19) patients in two centers of Hubei province, China: A retrospective analysis.
Xiao Bin Zhang,Xiao Bin Zhang,Lan Hu,Quan Ming,Xiao Jie Wei,Zhen-Yu Zhang,Li Da Chen,Ming Hui Wang,Ming Hui Wang,Weng Zhen Yao,Weng Zhen Yao,Qiu Fen Huang,Qiu Fen Huang,Zhang Qiang Ye,Zhang Qiang Ye,Yu Qing Cai,Yu Qing Cai,Hui Qing Zeng,Hui Qing Zeng +18 more
TL;DR: Low Hb, high LDH, PCT, and CT score on admission were the predictors for mortality and could assist clinicians in early identification of poor prognosis among COVID-19 patients.
References
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
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TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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