Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study.
Rong Hui Du,Li Rong Liang,Cheng Qing Yang,Wen Wang,Tan Ze Cao,Ming Li,Guang Yun Guo,Juan Du,Chun Lan Zheng,Qi Zhu,Ming Hu,Xu Yan Li,Peng Peng,Huan-Zhong Shi +13 more
TLDR
Age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1 were four risk factors predicting high mortality of COVID-19 pneumonia patients.Abstract:
The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2. All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression was performed to investigate the relationship between each variable and the risk of death of COVID-19 pneumonia patients. In total, 179 patients with COVID-19 pneumonia (97 male and 82 female) were included in the present prospective study, of whom 21 died. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.146‒17.394; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 0.755‒8.044; p=0.007), CD3+CD8+ T-cells ≤75 cells·μL−1 (OR 3.982, 95% CI 1.132‒14.006; p We identified four risk factors: age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1. The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients.read more
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Can we predict the severe course of COVID-19? A systematic review and meta-analysis of indicators of clinical outcome.
Stephan Katzenschlager,Alexandra J. Zimmer,Claudius Gottschalk,Juergen Grafeneder,Alexander Seitel,Lena Maier-Hein,Andrea Benedetti,Jan Larmann,Markus A. Weigand,Sean McGrath,Claudia M. Denkinger +10 more
TL;DR: This comprehensive meta-analysis found age, cerebrovascular disease, CRP, LDH and cTnI to be the most important risk-factors in predicting severe COVID-19 outcomes and will inform decision analytical tools to support clinical decision-making.
Journal ArticleDOI
Identification of Parameters Representative of Immune Dysfunction in Patients with Severe and Fatal COVID-19 Infection: a Systematic Review and Meta-analysis
Rundong Qin,Li He,Zhaowei Yang,Nan Jia,Ruchong Chen,Jiaxing Xie,Wanyi Fu,Haoxuan Chen,Xinliu Lin,Renbin Huang,Tianyue Luo,Yukai Liu,Simin Yao,Mei Jiang,Jing Li +14 more
TL;DR: In this paper , the authors conducted an electronic search of PubMed, Scopus, Ovid, Willey, Web of Science, Cochrane library, and CNKI for studies reporting immunological and/or immune related parameters, including hematological, inflammatory, coagulation, and biochemical variables, tested on hospital admission of COVID-19 patients with different severities and outcomes.
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Observational Study of Haloperidol in Hospitalized Patients with Covid-19
Nicolas Hoertel,Marina Sánchez Rico,Marina Sánchez Rico,Raphaël Vernet,Anne-Sophie Jannot,Antoine Neuraz,Antoine Neuraz,Carlos Blanco,Cédric Lemogne,Guillaume Airagnes,Nicolas Paris,Christel Daniel,Alexandre Gramfort,Guillaume Lemaitre,Mélodie Bernaux,Ali Bellamine,Nathanaël Beeker,Frédéric Limosin,Universities,Ap-Hp Covid Cdr Initiative +19 more
TL;DR: It is suggested that haloperidol is unlikely to have a clinical efficacy for Covid-19 as a potential effective treatment on the grounds of its in-vitro antiviral effects against SARS-CoV-2.
Journal ArticleDOI
Lymphocyte subsets early predict mortality in a large series of hospitalized COVID-19 patients in Spain.
S Cantenys-Molina,Eduardo Fernández-Cruz,P Francos,J C Lopez Bernaldo de Quirós,Patricia Muñoz,J Gil-Herrera +5 more
TL;DR: Reduced counts of CD4+ and CD8+ T cells with proportional expansion of NK lymphocytes at admission were prognostic factors of death in this Spanish series of SARS‐CoV‐2‐infected patients.
Journal ArticleDOI
Management of patients with SARS-CoV-2 infections and of patients with chronic lung diseases during the COVID-19 pandemic (as of 9 May 2020) : Statement of the Austrian Society of Pneumology (ASP).
Holger Flick,Britt Madelaine Arns,Josef Bolitschek,Brigitte Bucher,Katharina Cima,Elisabeth Gingrich,Sabin Handzhiev,Maximilian Hochmair,F. Horak,Marco Idzko,Peter Jaksch,Gabor Kovacs,R Kropfmüller,Bernd Lamprecht,Judith Löffler-Ragg,Michael Meilinger,Horst Olschewski,Andreas Pfleger,Bernhard Puchner,Christoph Puelacher,Christian Prior,Patricia Rodriguez,Helmut J F Salzer,Peter Schenk,Otmar Schindler,Ingrid Stelzmüller,Volker Strenger,Helmut Täubl,Matthias Urban,Marlies Wagner,Franz Wimberger,Angela Zacharasiewicz,Ralf H. Zwick,Ernst Eber +33 more
TL;DR: The treatment of patients with chronic lung diseases has to be adapted during the pandemic but must still be guaranteed; however, COVID-19 specific adjustments are useful.
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TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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