Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study.
Rong Hui Du,Li Rong Liang,Cheng Qing Yang,Wen Wang,Tan Ze Cao,Ming Li,Guang Yun Guo,Juan Du,Chun Lan Zheng,Qi Zhu,Ming Hu,Xu Yan Li,Peng Peng,Huan-Zhong Shi +13 more
TLDR
Age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1 were four risk factors predicting high mortality of COVID-19 pneumonia patients.Abstract:
The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2. All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression was performed to investigate the relationship between each variable and the risk of death of COVID-19 pneumonia patients. In total, 179 patients with COVID-19 pneumonia (97 male and 82 female) were included in the present prospective study, of whom 21 died. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.146‒17.394; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 0.755‒8.044; p=0.007), CD3+CD8+ T-cells ≤75 cells·μL−1 (OR 3.982, 95% CI 1.132‒14.006; p We identified four risk factors: age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1. The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients.read more
Citations
More filters
Journal ArticleDOI
Factors associated with disease severity and mortality among patients with COVID-19: A systematic review and meta-analysis.
Vignesh Chidambaram,Nyan Lynn Tun,Waqas Haque,Marie Gilbert Majella,Ranjith Kumar Sivakumar,Amudha Kumar,Angela Ting-Wei Hsu,Izza A. Ishak,Aqsha A. Nur,Samuel K. Ayeh,Emmanuella L. Salia,Ahsan Zil-E-Ali,Muhammad A. Saeed,Ayu P. B. Sarena,Bhavna Seth,Muzzammil Ahmadzada,Eman F. Haque,Pranita Neupane,Kuang Heng Wang,Tzu Miao Pu,Syed Muhammad Hammad Ali,Muhammad Asharib Arshad,Lin Wang,Sheriza N. Baksh,Petros C. Karakousis,Panagis Galiatsatos +25 more
TL;DR: Knowledge of the factors associated with disease severity and mortality identified in this study may assist in clinical decision-making and critical-care resource allocation for patients with COVID-19.
Journal ArticleDOI
Clinical characteristics of COVID-19 and active tuberculosis co-infection in an Italian reference hospital.
Claudia Stochino,Simone Villa,Patrizia Zucchi,Pierpaolo Parravicini,Andrea Gori,Andrea Gori,Mario Carlo Raviglione +6 more
TL;DR: The COVID-19 infection rate was high in patients with active tuberculosis, and major clinical complications were seen only in two patients, thus requiring ex novo oxygen supply, one of whom with advanced tuberculosis died.
Journal ArticleDOI
Risk factors for death in 1859 subjects with COVID-19.
Lei Chen,Jianming Yu,Wenjuan He,Li Chen,Guolin Yuan,Fang Dong,Wenlan Chen,Yulin Cao,Jingyan Yang,Liling Cai,Di Wu,Qijie Ran,Lei Li,Qiaomei Liu,Wenxiang Ren,Fei Gao,Hongxiang Wang,Zhichao Chen,Robert Peter Gale,Qiubai Li,Yu Hu +20 more
TL;DR: The authors' data identify covariates associated with risk of in hospital death in persons with COVID-19 and piecewise linear regression analyses Log 10 NLR the interval from ≥0.4 to ≤1.0 was significantly associated with an increased risk of death.
Journal ArticleDOI
Performance of pneumonia severity index and CURB-65 in predicting 30-day mortality in patients with COVID-19.
Celal Satici,Mustafa Asim Demirkol,Elif Sargin Altunok,Bengul Gursoy,Mustafa Alkan,Sadettin Kamat,Berna Demirok,Cemile Dilsah Surmeli,Mustafa Calik,Zuhal Cavus,Sinem Nihal Esatoglu +10 more
TL;DR: In a large group of hospitalized patients with COVID-19, it was found that PSI performed better than CURB-65 in predicting mortality, and higher CRP levels were associated with an increased risk for mortality.
Journal ArticleDOI
Risk factors for adverse clinical outcomes with COVID-19 in China: a multicenter, retrospective, observational study.
Peng Peng Xu,Rong Hua Tian,Song Luo,Zi Yue Zu,Bin Fan,Xi Ming Wang,Kai Xu,Jiang Tao Wang,Juan Zhu,Ji Chan Shi,Feng Chen,Bing Wan,Zhi Han Yan,Rong Pin Wang,Wen Chen,Wen Hui Fan,Can Zhang,Meng Jie Lu,Zhi Yuan Sun,Chang Sheng Zhou,Li Na Zhang,Fei Xia,Li Qi,Wei Zhang,Jing Zhong,Xiao Xue Liu,Qi Rui Zhang,Guang Ming Lu,Long Jiang Zhang +28 more
TL;DR: The risk factors of older age, multiple comorbidities, leukocytosis, lymphopenia and higher CT severity score could help clinicians identify patients with potential adverse events.
References
More filters
Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
Related Papers (5)
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more