Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study.
Rong Hui Du,Li Rong Liang,Cheng Qing Yang,Wen Wang,Tan Ze Cao,Ming Li,Guang Yun Guo,Juan Du,Chun Lan Zheng,Qi Zhu,Ming Hu,Xu Yan Li,Peng Peng,Huan-Zhong Shi +13 more
TLDR
Age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1 were four risk factors predicting high mortality of COVID-19 pneumonia patients.Abstract:
The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2. All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression was performed to investigate the relationship between each variable and the risk of death of COVID-19 pneumonia patients. In total, 179 patients with COVID-19 pneumonia (97 male and 82 female) were included in the present prospective study, of whom 21 died. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.146‒17.394; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 0.755‒8.044; p=0.007), CD3+CD8+ T-cells ≤75 cells·μL−1 (OR 3.982, 95% CI 1.132‒14.006; p We identified four risk factors: age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1. The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients.read more
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Hydroxychloroquine plus azithromycin and early hospital admission are beneficial in COVID-19 patients: Turkish experience with real-life data
Elif Tanriverdi,Mustafa Çörtük,Binnaz Zeynep Yildirim,Efsun Gonca Uğur Chousein,Demet Turan,Halit Çinarka,Mehmet Akif Özgül,Erdoğan Çetinkaya +7 more
TL;DR: Early treatment and early admission to the hospital can be crucial for the better treatment process and combination therapy with azithromycin may be preferred in the first treatment choice because it can shorten the length of hospital stay.
Journal ArticleDOI
Patients' treatment limitations as predictive factor for mortality in COVID-19: results from hospitalized patients of a hotspot region for SARS-CoV-2 infections.
Stephan Budweiser,Sevki Bas,Rudolf A. Jörres,Sebastian Engelhardt,Stefan von Delius,Katharina Lenherr,Jens Deerberg-Wittram,Andreas Bauer +7 more
TL;DR: In hospitalized patients with SARS-CoV-2, the percentage of patients with treatment limitations was high and PTL were linked to age, comorbidities and eGFR assessed upon admission and strong, independent risk factors for mortality.
Posted ContentDOI
Survival and predictors of deaths of patients hospitalized due to COVID-19 from a retrospective and multicenter cohort study in Brazil
Marquiony Marques dos Santos,Eudes Es Lucena,Kenio Costa de Lima,Andiara Ac Brito,Mônica Baumgardt Bay,Diego Bonfada +5 more
TL;DR: The overall survival time was low in hospitalizations for COVID-19 and this reinforces the importance of sociodemographic and clinical factors as a prognosis for death.
Elevated cardiac troponin I as a predictor of outcomes in COVID-19 hospitalizations: a meta-analysis.
TL;DR: It is suggested that COVID-19 patients with elevated troponin I levels had a higher risk of poor outcomes, which might be helpful in preventing risk of cardiac complications and other organ dysfunction.
Journal ArticleDOI
Peripheral T cell lymphopenia in COVID-19: potential mechanisms and impact
TL;DR: Measuring T cell dynamics during COVID-19 will inform clinical risk-stratification of hospitalised patients and could identify those who would benefit most from treatments that target T cells, particularly IL-6 pathways.
References
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TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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