Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study.
Rong Hui Du,Li Rong Liang,Cheng Qing Yang,Wen Wang,Tan Ze Cao,Ming Li,Guang Yun Guo,Juan Du,Chun Lan Zheng,Qi Zhu,Ming Hu,Xu Yan Li,Peng Peng,Huan-Zhong Shi +13 more
TLDR
Age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1 were four risk factors predicting high mortality of COVID-19 pneumonia patients.Abstract:
The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2. All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression was performed to investigate the relationship between each variable and the risk of death of COVID-19 pneumonia patients. In total, 179 patients with COVID-19 pneumonia (97 male and 82 female) were included in the present prospective study, of whom 21 died. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.146‒17.394; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 0.755‒8.044; p=0.007), CD3+CD8+ T-cells ≤75 cells·μL−1 (OR 3.982, 95% CI 1.132‒14.006; p We identified four risk factors: age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1. The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients.read more
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The common risk factors for progression and mortality in COVID-19 patients: a meta-analysis.
TL;DR: In this article, a systematic search of electronic databases (PubMed, Embase and Cochrane Library) for studies published before September 29, 2020, was performed to identify risk factors for COVID-19 severity and mortality.
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Core Outcome Measures for Trials in People With Coronavirus Disease 2019: Respiratory Failure, Multiorgan Failure, Shortness of Breath, and Recovery.
Allison Tong,Amanda Baumgart,Nicole Evangelidis,Andrea K. Viecelli,Simon A. Carter,Luciano Cesar Pontes Azevedo,Tess E Cooper,Andrew D. Bersten,Lilia Cervantes,Derek P. Chew,Sally Crowe,Ivor S. Douglas,Ivor S. Douglas,Ella Flemyng,Julian H Elliott,Elyssa Hannan,Peter Horby,Peter Horby,Martin Howell,Martin Howell,Angela Ju,Angela Ju,Jaehee Lee,Eduardo Lorca,Eduardo Lorca,Deena Lynch,Deena Lynch,Karine E. Manera,Karine E. Manera,John C. Marshall,Andrea Matus Gonzalez,Anne McKenzie,Sangeeta Mehta,Mervyn Mer,Andrew Conway Morris,Dale M. Needham,Saad Nseir,Pedro Póvoa,Mark Reid,Yasser Sakr,Ning Shen,Alan R Smyth,A. John Simpson,Tom Snelling,Tom Snelling,Giovanni F.M. Strippoli,Armando Teixeira-Pinto,Antoni Torres,Antoni Torres,Tari Turner,Steve Webb,Paula R Williamson,Paula R Williamson,Laila Woc-Colburn,Junhua Zhang,Jonathan C. Craig +55 more
TL;DR: In this paper, three online consensus workshops were convened to establish outcome measures for the four core domains of respiratory failure, multiple organ failure, shortness of breath, recovery, and mortality.
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Time to recovery from COVID-19 and its predictors among patients admitted to treatment center of Wollega University Referral Hospital (WURH), Western Ethiopia: Survival analysis of retrospective cohort study.
Tadesse Tolossa,Bizuneh Wakuma,Dejene Seyoum Gebre,Emiru Merdassa Atomssa,Motuma Getachew,Getahun Fetensa,Diriba Ayala,Ebisa Turi +7 more
TL;DR: In this paper, a hospital-based retrospective cohort study was conducted among 263 adult patients admitted with COVID-19 in WURH treatment center from March 29, 2020 through September 30, 2020.
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Organ-specific toxicity of magnetic iron oxide-based nanoparticles.
Vladimir V. Chrishtop,Vladimir Mironov,Artur Y. Prilepskii,Varvara G. Nikonorova,Vladimir V. Vinogradov +4 more
TL;DR: Tests conducted on animals with pathologies representing human chronic socially significant diseases are of great importance for further medical translation on nanomaterials to practice and should be taken into account for subsequent studies of the toxicity of iron oxide nanoparticles.
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Interplay between severities of COVID-19 and the gut microbiome: implications of bacterial co-infections?
TL;DR: In this article, the SARS-CoV-2 has been traced not only in nasopharyngeal and mid-nasal swabs but also in stool and rectal swab of COVID-19 patients.
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TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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