Journal ArticleDOI
Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: a retrospective analysis.
Yohei Mano,Ken Shirabe,Yo-ichi Yamashita,Norifumi Harimoto,Eiji Tsujita,Kazuki Takeishi,Shinichi Aishima,Toru Ikegami,Tomoharu Yoshizumi,Takeharu Yamanaka,Yoshihiko Maehara +10 more
TLDR
NLR is an independent predictor of survival after hepatectomy in patients with HCC and accumulation of tumor-associated macrophages in the tumor is associated with a high NLR.Abstract:
Objective:To clarify the prognostic value of the preoperative blood neutrophil-to-lymphocyte ratio (NLR) in patients undergoing hepatectomy for hepatocellular carcinoma (HCC).Background:Although a high NLR has been reported to be a predictor of poor survival in patients with various cancers, it hasread more
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Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma.
Bo Hu,Xin-Rong Yang,Yang Xu,Yun-Fan Sun,Chao Sun,Wei Guo,Xin Zhang,Wei-Min Wang,Shuang-Jian Qiu,Jian Zhou,Jia Fan +10 more
TL;DR: The novel systemic immune-inflammation index (SII) based on lymphocyte, neutrophil, and platelet counts was a powerful prognostic indicator of poor outcome in patients with HCC and is a promising tool for HCC treatment strategy decisions.
Journal ArticleDOI
Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib.
Shao-Lai Zhou,Zheng-Jun Zhou,Zhi-Qiang Hu,Xiao-Wu Huang,Zheng Wang,Er-Bao Chen,Jia Fan,Ya Cao,Zhi Dai,Jian Zhou +9 more
TL;DR: TAN-conditioned media, as well as recombinant CCL2 and CCL17, increased the migratory activity of the macrophages and T-regulatory cells from patients or mice with HCC to a greater extent that PBN- conditioned media.
Journal ArticleDOI
Prognostic role of neutrophil-to-lymphocyte ratio in colorectal cancer: a systematic review and meta-analysis.
Mu-Xing Li,Xuemin Liu,Xu-Feng Zhang,Jian-Fei Zhang,Wanli Wang,Ying Zhu,Jian Dong,Jiwen Cheng,Zhengwen Liu,Le Ma,Yi Lv +10 more
TL;DR: It is concluded that NLR gains a prognostic value for patients with CRC and should be monitored in CRC patients for rational stratification of the patients and adjusting the treatment strategy.
Journal ArticleDOI
The prognostic value of preoperative NLR, d-NLR, PLR and LMR for predicting clinical outcome in surgical colorectal cancer patients
Houqun Ying,Houqun Ying,Qiwen Deng,Bangshun He,Yuqin Pan,Feng Wang,Huiling Sun,Huiling Sun,Jie Chen,Jie Chen,Xian Liu,Shukui Wang,Shukui Wang +12 more
TL;DR: It is shown that preoperative elevated NLR can be considered as an independent prognostic biomarker for RFS, OS and CSS, and Nomograms containing NLR provide improved accuracy for predicting clinical outcomes in surgical CRC patients under surgery resection.
Journal ArticleDOI
From bench to bed: the tumor immune microenvironment and current immunotherapeutic strategies for hepatocellular carcinoma.
TL;DR: The recent progress on HCC immunology is provided from both basic and clinical perspectives, and potential advances and challenges of immunotherapy in HCC are discussed.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Time-Dependent ROC Curves for Censored Survival Data and a Diagnostic Marker
TL;DR: This work proposes summarizing the discrimination potential of a marker X, measured at baseline (t = 0), by calculating ROC curves for cumulative disease or death incidence by time t, which is presented as ROC(t), and presents an example where ROC (t) is used to compare a standard and a modified flow cytometry measurement for predicting survival after detection of breast cancer.
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Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill.
TL;DR: In the population of 90 ICU oncological patients, rapid serial changes in white blood cell populations are observed, as a response of the immune system to surgical stress, systemic inflammation or sepsis.
Journal ArticleDOI
A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-κB and enhanced IRF-3/STAT1 activation)
Subhra K. Biswas,Lisa Gangi,Saki Paul,Tiziana Schioppa,Alessandra Saccani,Marina Sironi,Barbara Bottazzi,Andrea Doni,Bronte Vincenzo,Fabio Pasqualini,Luca Vago,Manuela Nebuloni,Alberto Mantovani,Antonio Sica +13 more
TL;DR: In this article, the gene expression profile of TAMs isolated from a murine fibrosarcoma in comparison with peritoneal macrophages (PECs) and myeloid suppressor cells (MSCs), using a cDNA microarray technology, was characterized.