Preparation, Optimization and In-Vitro Evaluation of Curcumin-Loaded Niosome@calcium Alginate Nanocarrier as a New Approach for Breast Cancer Treatment.
Iman Akbarzadeh,Mona Shayan,Mahsa Bourbour,Maryam Moghtaderi,Hassan Noorbazargan,Faten Eshrati Yeganeh,Samaneh Saffar,Mohammadreza Tahriri +7 more
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In this article, an optimum formulation of curcumin-loaded niosomes with a calcium alginate shell (AL-NioC) was developed and optimized by a three-level Box-Behnken design.Abstract:
Cancer is one of the most common causes of mortality, and its various treatment methods can have many challenges for patients. As one of the most widely used cancer treatments, chemotherapy may result in diverse side effects. The lack of targeted drug delivery to tumor tissues can raise the possibility of damage to healthy tissues, with attendant dysfunction. In the present study, an optimum formulation of curcumin-loaded niosomes with a calcium alginate shell (AL-NioC) was developed and optimized by a three-level Box–Behnken design—in terms of dimension and drug loading efficiency. The niosomes were characterized by transmission electron microscopy, Fourier-transform infrared spectroscopy, and dynamic light scattering. The as-formulated niosomes showed excellent stability for up to 1 month at 4 °C. Additionally, the niosomal formulation demonstrated a pH-dependent release; a slow-release profile in physiological pH (7.4), and a more significant release rate at acidic conditions (pH = 3). Cytotoxicity studies showed high compatibility of AL-NioC toward normal MCF10A cells, while significant toxicity was observed in MDA-MB-231 and SKBR3 breast cancer cells. Gene expression studies of the cancer cells showed downregulation of Bcl2, cyclin D, and cyclin E genes, as well as upregulation of P53, Bax, caspase-3, and caspase-9 genes expression following the designed treatment. Flow cytometry studies confirmed a significant enhancement in the apoptosis rate in the presence of AL-NioC in both MDA-MB-231 and SKBR3 cells as compared to other samples. In general, the results of this study demonstrated that—thanks to its biocompatibility toward normal cells—the AL-NioC formulation can efficiently deliver hydrophobic drugs to target cancer cells while reducing side effects.read more
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Delivery of melittin-loaded niosomes for breast cancer treatment: an in vitro and in vivo evaluation of anti-cancer effect
Farnaz Dabbagh Moghaddam,Iman Akbarzadeh,Ehsan Marzbankia,Mahsa Farid,Leila khaledi,Amir Hossein Reihani,Mehrnoosh Javidfar,Pejman Mortazavi +7 more
TL;DR: Farnaz Dabbagh Moghaddam Islamic Azad University Science and Research Branch Iman Akbarzadeh Sharif university of Technology Ehsan Marzbankia Sharif University of Technology Mahsa Farid Shahid Beheshti University of Medical Sciences Leila Khaledi IslamicAzad University Tehran North Branch
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Synergistic effect of curcumin-Cu and curcumin-Ag nanoparticle loaded niosome: Enhanced antibacterial and anti-biofilm activities.
Arefeh Abolhassani Targhi,Ali Moammeri,Elham Jamshidifar,Koorosh Abbaspour,Somayeh Sadeghi,Lida Lamakani,Iman Akbarzadeh +6 more
TL;DR: In this paper, the synergistic activity of curcumin and silver/copper nanoparticles (NPs) was studied against Staphylococcus aureus and Pseudomonas aeruginosa.
Journal ArticleDOI
A novel pH‐responsive nanoniosomal emulsion for sustained release of curcumin from a chitosan‐based nanocarrier: Emphasis on the concurrent improvement of loading, sustained release, and apoptosis induction
Shabnam Haseli,Mehrab Pourmadadi,Amir Samadi,Fatemeh Yazdian,Majid Abdouss,Hamid Rashedi,Mona Navaei-Nigjeh +6 more
TL;DR: The current delivery platform improved loading, sustained release, and curcumin anti‐cancer effect, and this platform could be a potential candidate to mitigate cancer therapy restrictions withCurcumin.
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Curcumin: Modulator of Key Molecular Signaling Pathways in Hormone-Independent Breast Cancer
Reyhaneh Farghadani,Rakesh Naidu +1 more
TL;DR: Wang et al. as discussed by the authors highlighted the anticancer activity of curcumin in hormone-independent breast cancer via focusing on its impact on key signaling pathways including the PI3K/Akt/mTOR pathway, JAK/STAT pathway, MAPK pathway, NF-ĸB pathway, p53 pathway, and Wnt/β-catenin, as well as apoptotic and cell cycle pathways.
Journal ArticleDOI
Enhanced Antibacterial Activity of Echinacea angustifolia Extract against Multidrug-Resistant Klebsiella pneumoniae through Niosome Encapsulation
Maryam Moghtaderi,Amir Mirzaie,Negar Zabet,Ali Moammeri,Amirreza Mansoori-Kermani,Iman Akbarzadeh,Faten Eshrati Yeganeh,Arman Chitgarzadeh,Aliasghar Bagheri Kashtali,Qun Ren +9 more
TL;DR: In this article, a niosome-encapsulated Echinacea angustifolia extract was used to study its efficacy against multidrug-resistant Klebsiella pneumoniae strains.
References
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Journal ArticleDOI
In vitro study of polyoxyethylene alkyl ether niosomes for delivery of insulin
TL;DR: Results indicate that niosomes could be developed as sustained release oral dosage forms for delivery of peptides and proteins such as insulin.
Journal ArticleDOI
Cancer statistics for adults aged 85 years and older, 2019
Carol DeSantis,Kimberly D. Miller,William Dale,Supriya G. Mohile,Harvey J. Cohen,Corinne R. Leach,Ann Goding Sauer,Ahmedin Jemal,Rebecca L. Siegel +8 more
TL;DR: Overall cancer incidence rates peaked in the oldest men and women around 1990 and have subsequently declined, with the pace accelerating during the past decade, and trends largely reflect declines in cancers of the prostate and colorectum and, more recently, cancer of the lung among men and the breast among women.
Journal ArticleDOI
Degradation of polysorbates 20 and 80: studies on thermal autoxidation and hydrolysis.
Ravuri S. K. Kishore,Astrid Pappenberger,Isabelle Bauer Dauphin,Alfred Ross,Beatrice Buergi,Andreas Staempfli,Hanns-Christian Mahler +6 more
TL;DR: The purpose of this work was to study the mechanistic pathways of degradation of polysorbates (PS) 20 and PS80 in parenteral formulations, and found that PSs degrade mainly via autoxidation and also via hydrolysis at higher temperatures.
Journal ArticleDOI
Oral colon-specific drug delivery for bee venom peptide: development of a coated calcium alginate gel beads-entrapped liposome.
TL;DR: The results clearly demonstrated that the coated calcium alginate gel beads-entrapped liposome is a potential system for colon-specific drug delivery.
Journal ArticleDOI
Calcium alginate-carboxymethyl cellulose beads for colon-targeted drug delivery
Tarun Agarwal,S. N. Gautham Hari Narayana,Kunal Pal,Krishna Pramanik,Supratim Giri,Indranil Banerjee +5 more
TL;DR: Cytotoxicity data, nuclear condensation-fragmentation and apoptosis analysis together confirmed the therapeutic potential of the CA-CMC formulations and they can be used for colon-specific drug delivery.