Journal ArticleDOI
Prevention of Carbon Tetrachloride-Induced Hepatotoxicity by the Ethanol Extract of Capparis moonii Fruits in Rats
Mohd Tarmizi Ali,Ramidi Ramachandram,Mohamed Rafiullah,Onkar Singh,Abdul Wadood Siddiqui,Showkat R. Mir +5 more
TLDR
The extract of C. moonii produced significant lowering of the elevated Serum glutamic oxaloacetic transaminace (SGOT) Serumglutamicpyraric transaminase (SGPT), alkaline phosphatase (ALP), and a rise of depleted total protein when compared with the toxic control.Abstract:
The effect of the ethanol extract of Capparis moonii Hook f Thoms (Capparidaceae) fruits was studied in carbon tetrachloride (CCl4)-induced hepatotoxicity in rats The hepatotoxicity was induced in rats with the administration of 1 : 1 (v/v) mixture of CCl4 in olive oil at the dose of 1 ml/kg subcutaneously on day 7 The ethanol extract of C moonii (200 mg/kg) and the standard drug silymarin (25 mg/kg) were given orally from day 1 to day 9 The extract of C moonii produced significant (p < 0001) lowering of the elevated Serum glutamic oxaloacetic transaminace (SGOT) Serum glutamicpyraric transaminase (SGPT), alkaline phosphatase (ALP), and a rise of depleted total protein when compared with the toxic control The results were comparable with the standard drug silymarinread more
Citations
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Hepatoprotective Activity of Methanol Extract of Tecomella undulata against Alcohol and Paracetamol Induced Hepatotoxicity in Rats
TL;DR: Findings indicate the hepatoprotective potential of T. undulata leaves against liver damage might be due to the presence of flavonoids, quinones and other bioactive constituents.
Journal ArticleDOI
Lead finding from medicinal plants with hepatoprotective potentials.
TL;DR: An attempt has been made through this article to review the most potential medicinal plants with pharmacologically established hepatoprotective activity and finds the effective leads from natural resources for the desired therapeutic benefit.
Journal Article
A review on chemical and medicobiological applications of Capparidaceae family.
TL;DR: The diverse phytoconstituents and various medicobiological uses of the plants belonging to the Capparidaceae family were reviewed here.
Journal ArticleDOI
Hepatoprotective effect of leaves of aqueous ethanol extract of Cestrum nocturnum against paracetamol-induced hepatotoxicity
TL;DR: It was concluded from the present study that aqueous ethanol extract of leaves of C. nocturnum has hepatoprotective activity against the paracetamol-induced hepatotoxicity in albino mice.
Journal ArticleDOI
Prevalence and current therapy in chronic liver disorders.
Muhammad Daniyal,Muhammad Akram,Rida Zainab,Naveed Munir,Aamir Sharif,Syed Muhammad Ali Shah,Bin Liu,Wei Wang +7 more
TL;DR: This review shows that numerous plants are found to contain hepatoprotective compounds, however, further studies are needed to determine their association with existing regimes of antiviral medicines and to develop evidence-based alternative medicine to cure different kinds of liver disease in humans.
References
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Journal ArticleDOI
A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.
Stanley Reitman,Sam Frankel +1 more
Journal ArticleDOI
Estimation of Plasma Phosphatase by Determination of Hydrolysed Phenol with Amino-antipyrine
P. R. N. Kind,E. J. King +1 more
TL;DR: The conditions under which enzymic hydrolysis is carried out are the same as in the King-Armstrong method, as modified by King (1951), the amino-antipyrine reagent (A.A.P.) being used to estimate the phenol liberated.
Journal Article
Carbon tetrachloride hepatotoxicity
TL;DR: The knowledge that hepatic triglyceride secretion involves a dual mechanism has provided a powerful new guide for the analysis of mechanisms underlying fatty liver disease, and a central requirement of this hypothesis must be that if over supply of fatty acids is to be invoked as a significant factor in the pathogenesis of fatty liver, then the oversupply must be of sufficient magnitude and duration.
Journal Article
Screening of Indian plants for biological activity: Part X.
Journal Article
Hepatoprotective activity of verbenalin on experimental liver damage in rodents
TL;DR: A significant hepatoprotective effect was observed as evident from shortened hexobarbitone sleeping time and zoxazolamine paralysis time in mice which were increased by CCl 4 treatment.