Journal ArticleDOI
Primary open-angle glaucoma.
Robert N. Weinreb,Christopher Kai-Shun Leung,Jonathan G Crowston,Felipe A. Medeiros,David S. Friedman,Janey L. Wiggs,Keith R Martin +6 more
- Vol. 2, Iss: 1, pp 16067-16067
TLDR
Primary open-angle glaucoma (POAG) is the most common type and management of POAG includes topical drug therapies and surgery to reduce IOP, although new therapies targeting neuroprotection of RGCs and axonal regeneration are under development.Abstract:
Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible blindness worldwide, but typically remains asymptomatic until very severe. Open-angle glaucoma comprises the majority of cases in the United States and western Europe, of which, primary open-angle glaucoma (POAG) is the most common type. By contrast, in China and other Asian countries, angle-closure glaucoma is highly prevalent. These two types of glaucoma are characterized based on the anatomic configuration of the aqueous humour outflow pathway. The pathophysiology of POAG is not well understood, but it is an optic neuropathy that is thought to be associated with intraocular pressure (IOP)-related damage to the optic nerve head and resultant loss of retinal ganglion cells (RGCs). POAG is generally diagnosed during routine eye examination, which includes fundoscopic evaluation and visual field assessment (using perimetry). An increase in IOP, measured by tonometry, is not essential for diagnosis. Management of POAG includes topical drug therapies and surgery to reduce IOP, although new therapies targeting neuroprotection of RGCs and axonal regeneration are under development.read more
Citations
More filters
Journal ArticleDOI
The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults
TL;DR: ROS are associated with the pathophysiological parainflammation and autophagy process in the course of the age-related macular degeneration and stimulate inflammation and pathological angiogenesis in the Course of diabetic retinopathy.
Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1
Kathryn P. Burdon,Stuart MacGregor,Alex W. Hewitt,Shiwani Sharma,Glyn Chidlow,Richard A. Mills,Patrick Danoy,Robert J Casson,Ananth C. Viswanathan,Jimmy Z. Liu,John Landers,Anjali K. Henders,John P. M. Wood,Emmanuelle Souzeau,April Crawford,Paul Leo,Jie Jin Wang,Elena Rochtchina,Dale R. Nyholt,Nicholas G. Martin,Grant W. Montgomery,Paul Mitchell,Brown,David A. Mackey,Jamie E Craig +24 more
TL;DR: This paper reported a genome-wide association study for open-angle glaucoma (OAG) blindness using a discovery cohort of 590 individuals with severe visual field loss (cases) and 3,956 controls.
Journal ArticleDOI
Regional Comparisons of Optical Coherence Tomography Angiography Vessel Density in Primary Open-Angle Glaucoma
Harsha L. Rao,Zia S. Pradhan,Robert N. Weinreb,Hemanth B. Reddy,Mohammed Riyazuddin,Srilakshmi Dasari,Meena Palakurthy,Narendra K. Puttaiah,Dhanaraj A.S. Rao,Carroll A.B. Webers +9 more
TL;DR: Diagnostic abilities of vessel densities increased with increasing severity of glaucoma and that of ONH vessel density with higher pretreatment IOPs and ROC regression was used to evaluate the effect of covariates on the diagnostic abilities.
Journal ArticleDOI
Non-viral gene therapy: Gains and challenges of non-invasive administration methods.
Marianna Foldvari,Ding Wen Chen,Nafiseh Nafissi,Daniella Calderon,Lokesh Narsineni,Amirreza Rafiee +5 more
TL;DR: An overview of gene-based therapies focusing on non-viral gene delivery systems and the genetic therapeutic tools that will further revolutionize medical treatment is presented with primary focus on the range and development of non-invasive delivery systems for dermal, transdermal, ocular and pulmonary administrations.
Journal ArticleDOI
The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel
Aleksanteri Aspelund,Tuomas Tammela,Salli Antila,Harri Nurmi,Veli-Matti Leppänen,Georgia Zarkada,Lukas Stanczuk,Mathias Francois,Taija Makinen,Pipsa Saharinen,Ilkka Immonen,Kari Alitalo +11 more
TL;DR: The evolutionary conservation of the lymphatic-like phenotype of the Schlemm's canal is revealed, VEGF-C and VEGFR-3 are implicate as critical regulators of SC lymphangiogenesis, and provide a basis for further studies on therapeutic manipulation of the SC with VEGf-C in glaucoma treatment.
References
More filters
Journal ArticleDOI
Systematic review and meta-analysis
TL;DR: In this review the usual methods applied in systematic reviews and meta-analyses are outlined, and the most common procedures for combining studies with binary outcomes are described, illustrating how they can be done using Stata commands.
Journal ArticleDOI
Meta-Analysis: A Constantly Evolving Research Integration Tool
TL;DR: The four articles in this special section onMeta-analysis illustrate some of the complexities entailed in meta-analysis methods and contributes both to advancing this methodology and to the increasing complexities that can befuddle researchers.
Journal ArticleDOI
The number of people with glaucoma worldwide in 2010 and 2020
Harry A. Quigley,Aimee T. Broman +1 more
TL;DR: Glaucoma is the second leading cause of blindness worldwide, disproportionately affecting women and Asians, and it will be 60.5 million people with OAG and ACG in 2010, increasing to 79.6 million by 2020, and of these, 74% will have OAG.
Journal ArticleDOI
Number of people with glaucoma worldwide.
TL;DR: Improved methods of screening and therapy for glaucoma are urgently needed, as it is the second leading cause of vision loss in the world.
Journal ArticleDOI
Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis.
TL;DR: The global prevalence of primary open-angle glaucoma (POAG) and primary angle-closure glauComa (PACG) and the number of affected people in 2020 and 2040 are examined, disproportionally affecting people residing in Asia and Africa.
Related Papers (5)
The Pathophysiology and Treatment of Glaucoma: A Review
The number of people with glaucoma worldwide in 2010 and 2020
Harry A. Quigley,Aimee T. Broman +1 more