Probing compulsive and impulsive behaviors, from animal models to endophenotypes: a narrative review.
Naomi A. Fineberg,Naomi A. Fineberg,Naomi A. Fineberg,Marc N. Potenza,Samuel R. Chamberlain,Samuel R. Chamberlain,Heather A. Berlin,Lara Menzies,Antoine Bechara,Barbara J. Sahakian,Trevor W. Robbins,Edward T. Bullmore,Edward T. Bullmore,Eric Hollander +13 more
TLDR
It is suggested that impulsivity and compulsivity each seem to be multidimensional, and Serotonin and dopamine interact across these circuits to modulate aspects of both impulsive and compulsive responding and as yet unidentified brain-based systems may also have important functions.About:
This article is published in Neuropsychopharmacology.The article was published on 2010-02-01 and is currently open access. It has received 595 citations till now. The article focuses on the topics: Compulsive behavior & Orbitofrontal cortex.read more
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Inhibition and impulsivity: Behavioral and neural basis of response control
Andrea Bari,Trevor W. Robbins +1 more
TL;DR: This review will review the current models of behavioral inhibition along with their expression via underlying brain regions, including those involved in the activation of the brain's emergency 'brake' operation, those engaged in more controlled and sustained inhibitory processes and other ancillary executive functions.
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Reward, dopamine and the control of food intake: implications for obesity
TL;DR: Imaging studies show that obese subjects might have impairments in dopaminergic pathways that regulate neuronal systems associated with reward sensitivity, conditioning and control, and it is postulated that this could also be a mechanism by which overeating and the resultant resistance to homoeostatic signals impairs the function of circuits involved in reward sensitivity.
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Introduction to Behavioral Addictions
TL;DR: Growing evidence suggests that behavioral addictions resemble substance addictions in many domains, including natural history, phenomenology, tolerance, comorbidity, overlapping genetic contribution, neurobiological mechanisms, and response to treatment, supporting the DSM-V Task Force proposed new category of Addiction and Related Disorders encompassing both substance use disorders and non-substance addictions.
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Reward mechanisms in obesity: new insights and future directions.
TL;DR: Recent advances in the understanding of the brain circuitries that regulate hedonic aspects of feeding behavior will be reviewed and emerging evidence suggesting that obesity and drug addiction may share commonHedonic mechanisms will also be considered.
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Obesity and addiction: neurobiological overlaps.
TL;DR: For instance, this paper found that both obese and drug-addicted individuals suffer from impairments in dopaminergic pathways that regulate neuronal systems associated not only with reward sensitivity and incentive motivation, but also with conditioning, self-control, stress reactivity and interoceptive awareness.
References
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TL;DR: The authors discuss the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics.
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Getting Formal with Dopamine and Reward
TL;DR: Recent neurophysiological studies reveal that neurons in certain brain structures carry specific signals about past and future rewards, and the optimal use of rewards in voluntary behavior would benefit from interactions between the signals.
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Drug Abuse: Hedonic Homeostatic Dysregulation
TL;DR: This framework provides a realistic approach to identifying the neurobiological factors that produce vulnerability to addiction and to relapse in individuals with a history of addiction.