Reward, dopamine and the control of food intake: implications for obesity
TLDR
Imaging studies show that obese subjects might have impairments in dopaminergic pathways that regulate neuronal systems associated with reward sensitivity, conditioning and control, and it is postulated that this could also be a mechanism by which overeating and the resultant resistance to homoeostatic signals impairs the function of circuits involved in reward sensitivity.About:
This article is published in Trends in Cognitive Sciences.The article was published on 2011-01-01 and is currently open access. It has received 1099 citations till now. The article focuses on the topics: Dopaminergic pathways & Overeating.read more
Citations
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Gut feelings: the emerging biology of gut–brain communication
TL;DR: A complex, bidirectional communication system that not only ensures the proper maintenance of gastrointestinal homeostasis and digestion but is likely to have multiple effects on affect, motivation and higher cognitive functions, including intuitive decision making is revealed.
Journal ArticleDOI
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
TL;DR: Treatment with new agents results in an improvement in mood ratings within hours of dosing patients who are resistant to typical antidepressants, and these new agents have also been shown to reverse the synaptic deficits caused by stress.
Journal ArticleDOI
Obesity and addiction: neurobiological overlaps.
TL;DR: For instance, this paper found that both obese and drug-addicted individuals suffer from impairments in dopaminergic pathways that regulate neuronal systems associated not only with reward sensitivity and incentive motivation, but also with conditioning, self-control, stress reactivity and interoceptive awareness.
Journal ArticleDOI
Food cue reactivity and craving predict eating and weight gain: a meta-analytic review.
Rebecca G. Boswell,Hedy Kober +1 more
TL;DR: The present findings suggest that food cue reactivity, cue‐induced craving and tonic craving systematically and prospectively predict food‐related outcomes.
Book ChapterDOI
Food and drug reward: overlapping circuits in human obesity and addiction.
TL;DR: Results suggest that both obese and drug-addicted individuals suffer from impairments in dopaminergic pathways that regulate neuronal systems associated not only with reward sensitivity and incentive motivation, but also with conditioning, impulse control, stress reactivity, and interoceptive awareness.
References
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Cynthia L. Ogden,Margaret D. Carroll,Lester R. Curtin,Margaret McDowell,Carolyn J. Tabak,Katherine M. Flegal +5 more
TL;DR: These estimates suggest that the increases in body weight are continuing in men and in children and adolescents while they may be leveling off in women; among women, no overall increases in the prevalence of obesity were observed.
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OtherDOI
Prevalence of Overweight and Obesity in the United States
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Annual Medical Spending Attributable To Obesity: Payer-And Service-Specific Estimates
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Journal ArticleDOI
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
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Hirschhorn,Erik Ingelsson,Ruth J. F. Loos +413 more
TL;DR: Genetic loci associated with body mass index map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor, which may provide new insights into human body weight regulation.
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