Journal ArticleDOI
Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions.
TLDR
The small amounts of rat kidney proteins used, support the interpretation that an isoand autosensitization mechanism is at play, and help clarify the mechanism behind the severe nephrotic syndrome noted in 20 rats given Freund's adjuvants and a supernate of rat kidneys suspension by intraperitoneal injection.Abstract:
Summary1) A severe nephrotic syndrome was noted in 20 rats given Freund's adjuvants and a supernate of rat kidney suspension by intraperitoneal injection. When kidney tissue was replaced by liver, only 3 of 21 animals developed a much milder renal disease. Lung or muscle suspensions failed to induce proteinuria in 10 rats. 2) In large doses (0.5 ml) Freund's adjuvants alone produced a mild nephrotic disease in 3 of 10 rats. Even though the smaller amounts of the adjuvants usually used (0.25 ml) never produced proteinuria, slight histological alterations of the glomerular structure were frequently noted. 3) In contradistinction to other tissue suspensions addition of rat kidney supernate enhanced the effect of adjuvants markedly and regularly. 4) The small amounts of rat kidney proteins used, support the interpretation that an isoand autosensitization mechanism is at play.read more
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Animal models of nephrotic syndrome
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Chia-Chao Wu,Jin-Shuen Chen,Ching-Feng Huang,Chun-Chi Chen,Kuo-Chen Lu,Pauling Chu,Huey-Kang Sytwu,Yuh Feng Lin +7 more
TL;DR: The murine MN model resembled the clinical and pathological features of human MN and may provide a tool for investigating MN, and applying cDNA microarray analysis may help to identify biomarkers for human MN.
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Membranous Nephropathy: A Long Road but Well Traveled
TL;DR: My job as Guest Editor of this symposium is to put the four separate articles that it contains into context and tie them together as one cohesive feature.