Journal ArticleDOI
Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions.
TLDR
The small amounts of rat kidney proteins used, support the interpretation that an isoand autosensitization mechanism is at play, and help clarify the mechanism behind the severe nephrotic syndrome noted in 20 rats given Freund's adjuvants and a supernate of rat kidneys suspension by intraperitoneal injection.Abstract:
Summary1) A severe nephrotic syndrome was noted in 20 rats given Freund's adjuvants and a supernate of rat kidney suspension by intraperitoneal injection. When kidney tissue was replaced by liver, only 3 of 21 animals developed a much milder renal disease. Lung or muscle suspensions failed to induce proteinuria in 10 rats. 2) In large doses (0.5 ml) Freund's adjuvants alone produced a mild nephrotic disease in 3 of 10 rats. Even though the smaller amounts of the adjuvants usually used (0.25 ml) never produced proteinuria, slight histological alterations of the glomerular structure were frequently noted. 3) In contradistinction to other tissue suspensions addition of rat kidney supernate enhanced the effect of adjuvants markedly and regularly. 4) The small amounts of rat kidney proteins used, support the interpretation that an isoand autosensitization mechanism is at play.read more
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Glomérulonéphrite extramembraneuse : mécanismes et histoire naturelle
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Translational Aspects of Primary Membranous Nephropathy
Elion Hoxha,Rolf A.K. Stahl +1 more
TL;DR: Membranous nephropathy in an autoimmune disease caused by binding of circulating antibodies to podocytic antigens is described, a perfect example of how patient care may profit from the convergence of scientific and clinical achievements and the benefits of translational approaches in medicine.
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Nephrotic syndrome and hepatitis due to acquired syphilis: an uncommon presentation of a re-emerging disease
TL;DR: The diagnostic dilemma that was the case of a 41-year-old gentleman who presented to hospital with a profound nephrotic syndrome, rash and simultaneous hepatitis was reported, and a unifying diagnosis of secondary syphilis was made.