Journal ArticleDOI
Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions.
TLDR
The small amounts of rat kidney proteins used, support the interpretation that an isoand autosensitization mechanism is at play, and help clarify the mechanism behind the severe nephrotic syndrome noted in 20 rats given Freund's adjuvants and a supernate of rat kidneys suspension by intraperitoneal injection.Abstract:
Summary1) A severe nephrotic syndrome was noted in 20 rats given Freund's adjuvants and a supernate of rat kidney suspension by intraperitoneal injection. When kidney tissue was replaced by liver, only 3 of 21 animals developed a much milder renal disease. Lung or muscle suspensions failed to induce proteinuria in 10 rats. 2) In large doses (0.5 ml) Freund's adjuvants alone produced a mild nephrotic disease in 3 of 10 rats. Even though the smaller amounts of the adjuvants usually used (0.25 ml) never produced proteinuria, slight histological alterations of the glomerular structure were frequently noted. 3) In contradistinction to other tissue suspensions addition of rat kidney supernate enhanced the effect of adjuvants markedly and regularly. 4) The small amounts of rat kidney proteins used, support the interpretation that an isoand autosensitization mechanism is at play.read more
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Journal ArticleDOI
Glomerulonephritis induced in sheep by injections of heterologous glomerular basement membrane and Freund's complete adjuvant.
TL;DR: The passive transfer of nephritis by serum antibodies marks the first successful instance of transfer ofnephritisby serum antibody to a heterologous species from an animal which had developed nephitis itself.
Journal ArticleDOI
Autoimmunity in Membranous Nephropathy Targets Aldose Reductase and SOD2
Marco Prunotto,Maria Luisa Carnevali,Giovanni Candiano,Corrado Murtas,Maurizio Bruschi,Emilia Corradini,Antonella Trivelli,Alberto Magnasco,Andrea Petretto,Laura Santucci,Silvia Mattei,Rita Gatti,Francesco Scolari,Peter Kador,Landino Allegri,Gian Marco Ghiggeri +15 more
TL;DR: The data support AR and SOD2 as renal antigens of human MN and suggest that oxidative stress may drive glomerular SOD1 expression, while preliminary in vitro experiments showed an increase of S OD2 expression on podocyte plasma membrane after treatment with hydrogen peroxide.
Journal ArticleDOI
Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies
Hanna Debiec,Jeroen Nauta,Florence Coulet,Mirjam van der Burg,Vincent Guigonis,Thierry Schurmans,Emile de Heer,Florent Soubrier,Françoise Janssen,Pierre Ronco +9 more
TL;DR: It is shown that disease caused by fetomaternal alloimmunisation secondary to a genetic defect is not restricted to blood cells and should be considered as a leading cause of membranous glomerulopathy early in life.
Journal ArticleDOI
Autologous immune complex nephritis induced with renal tubular antigen. II. The pathogenetic mechanism.
TL;DR: It appears that this disease results from the formation of circulating antibodies capable of reacting with autologous renal tubular antigen and the deposition of these antibodies and antigen(s) plus complement apparently as immune complexes in the glomeruli.
Journal ArticleDOI
Membranous nephropathy: recent travels and new roads ahead.
Laurence H. Beck,David J. Salant +1 more
TL;DR: It is predicted that a widely available assay for anti-PLA2R will prove to be valuable for diagnosing IMN, distinguishing it from secondary MN, and evaluating response to therapy.