Journal ArticleDOI
Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions.
TLDR
The small amounts of rat kidney proteins used, support the interpretation that an isoand autosensitization mechanism is at play, and help clarify the mechanism behind the severe nephrotic syndrome noted in 20 rats given Freund's adjuvants and a supernate of rat kidneys suspension by intraperitoneal injection.Abstract:
Summary1) A severe nephrotic syndrome was noted in 20 rats given Freund's adjuvants and a supernate of rat kidney suspension by intraperitoneal injection. When kidney tissue was replaced by liver, only 3 of 21 animals developed a much milder renal disease. Lung or muscle suspensions failed to induce proteinuria in 10 rats. 2) In large doses (0.5 ml) Freund's adjuvants alone produced a mild nephrotic disease in 3 of 10 rats. Even though the smaller amounts of the adjuvants usually used (0.25 ml) never produced proteinuria, slight histological alterations of the glomerular structure were frequently noted. 3) In contradistinction to other tissue suspensions addition of rat kidney supernate enhanced the effect of adjuvants markedly and regularly. 4) The small amounts of rat kidney proteins used, support the interpretation that an isoand autosensitization mechanism is at play.read more
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Effects of rapamycin on active Heymann nephritis.
Radomir Naumovic,Djurdjica Jovovic,Gordana Basta-Jovanovic,Zoran Miloradovic,Nevena Mihailovic-Stanojevic,Tamara Aleksic,Dijana Jovanovic +6 more
TL;DR: RAPA demonstrated beneficial effects on disease progression, given either in the induction phase or during evolving HN, and it would be desirable to investigate the effect of RAPA on patients with MN.
Journal ArticleDOI
Molecular Dissection of Target Antigens and Nephritogenic Antibodies in Membranous Nephropathy: Towards Epitope-Driven Therapies
Pierre Ronco,Hanna Debiec +1 more
TL;DR: Membranous nephropathy is the most common cause of idiopathic nephrotic syndrome in white adults, and the disease is characterized by an accumulation of immune deposits on the outer aspect of the glomerular basement membrane.
Journal ArticleDOI
Production of Heymann nephritis by a chemically modified renal antigen
TL;DR: This is the first time that the autoimmune kidney disease designated as an active HN has been produced by the administration of a chemically altered renal antigen in an aqueous solution and not by the usual presentation of the nephritogenic renal antigenIn an adjuvant.
Journal ArticleDOI
Isolation of a 330-kDa glycoprotein from human kidney similar to the Heymann nephritis autoantigen (gp330).
TL;DR: It is demonstrated that there is a gp330 protein in human kidney that is very similar to the putative autoantigen of Heymann nephritis.