Journal ArticleDOI
Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions.
TLDR
The small amounts of rat kidney proteins used, support the interpretation that an isoand autosensitization mechanism is at play, and help clarify the mechanism behind the severe nephrotic syndrome noted in 20 rats given Freund's adjuvants and a supernate of rat kidneys suspension by intraperitoneal injection.Abstract:
Summary1) A severe nephrotic syndrome was noted in 20 rats given Freund's adjuvants and a supernate of rat kidney suspension by intraperitoneal injection. When kidney tissue was replaced by liver, only 3 of 21 animals developed a much milder renal disease. Lung or muscle suspensions failed to induce proteinuria in 10 rats. 2) In large doses (0.5 ml) Freund's adjuvants alone produced a mild nephrotic disease in 3 of 10 rats. Even though the smaller amounts of the adjuvants usually used (0.25 ml) never produced proteinuria, slight histological alterations of the glomerular structure were frequently noted. 3) In contradistinction to other tissue suspensions addition of rat kidney supernate enhanced the effect of adjuvants markedly and regularly. 4) The small amounts of rat kidney proteins used, support the interpretation that an isoand autosensitization mechanism is at play.read more
Citations
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Journal ArticleDOI
Autologous immune complex glomerulonephritis induces abnormal embryonic development
TL;DR: Young female random-bred Wistar rats were immunized with homologous renal brush border membranes and exhibited all the clinical and immunopathological characteristics of chronic autologous immune complex glomerulonephritis (Heymann nephritis) closely resembling the idiopathic membranous glomersul onephritis in humans.
Journal ArticleDOI
Mechanisms of Primary Membranous Nephropathy.
TL;DR: In this article, the authors discuss recent developments over the past 5 years and discuss the role of exostosin 1, EXT2, NELL-1, and contactin 1 (CNTN1) in the development of Membranous Nephropathy (MN).
Journal ArticleDOI
Renal leptin in experimental nephrotic syndrome
Abdelgawad A. Fahmi,Dawoud Fakhry Habib,Naglaa Mohamed Kholousy,Ahmed Ibrahim Amin,M. A. Shalaby,Mohamed Mahmoud Ahmed,Asem Metwally Abo Shanab +6 more
TL;DR: If the nephrotic kidneys participate in the metabolism of leptin by comparing the serum leptin level in renal veins and in their renal arteries and to study the relationship between leptin and lipoprotein levels in healthy and neph Rotic rats.
Journal ArticleDOI
Fixation and embedding variables in the immuno-electron microscopic study of rat heymann nephritis
TL;DR: Fixation and embedding variables were compared in immuno-electron microscopic localization of rat IgG in an autologous immune complextype nephritis and periodate-lysine-paraformaldehyde proved almost as useful as paraformaldehyde in connection with agarose in respect of peroxidase reaction and ultrastructure.
Book ChapterDOI
The Pathogenesis of Autologous Immune Complex Glomerulonephritis in Rats
TL;DR: A number of additional autologous antigen-antibody systems capable of evoking glomerular injury have been described in both animals and man.