Journal ArticleDOI
Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions.
TLDR
The small amounts of rat kidney proteins used, support the interpretation that an isoand autosensitization mechanism is at play, and help clarify the mechanism behind the severe nephrotic syndrome noted in 20 rats given Freund's adjuvants and a supernate of rat kidneys suspension by intraperitoneal injection.Abstract:
Summary1) A severe nephrotic syndrome was noted in 20 rats given Freund's adjuvants and a supernate of rat kidney suspension by intraperitoneal injection. When kidney tissue was replaced by liver, only 3 of 21 animals developed a much milder renal disease. Lung or muscle suspensions failed to induce proteinuria in 10 rats. 2) In large doses (0.5 ml) Freund's adjuvants alone produced a mild nephrotic disease in 3 of 10 rats. Even though the smaller amounts of the adjuvants usually used (0.25 ml) never produced proteinuria, slight histological alterations of the glomerular structure were frequently noted. 3) In contradistinction to other tissue suspensions addition of rat kidney supernate enhanced the effect of adjuvants markedly and regularly. 4) The small amounts of rat kidney proteins used, support the interpretation that an isoand autosensitization mechanism is at play.read more
Citations
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Idiopathic membranous nephropathy: Evolution in understanding the problem
TL;DR: The findings constituted the basis for developing current methods for the diagnosis and treatment of MN, including the pathogenetically sound inhibition of autoantibody production, as well as a molecular orientation effect on podocyte dysfunction.
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Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment
Edmund Y.M. Chung,Yuan Min Wang,Karen L. Keung,Min Hu,Hugh J. McCarthy,Germaine Wong,Lukas Kairaitis,Bhadran Bose,David Harris,J. Alexander +9 more
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Immune pathological examinations based on renal biopsy in glomerulonephritic children.
TL;DR: The results of renal biopsy performed on 15 children are analyzed from clinical, histological and immunomorphological points of view, and therapeutical possibilities are discussed.
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Thymocytes Reacting with Heterologous Antibodies against GP 330 in Autologous Immune Complex Glomerulopathy (AICG) in the Rat: The Relation between Susceptibility for AICG and Anti-GP 330-Binding Thymocytes
TL;DR: The correlation between the numbers of anti-GP 330-binding thymocytes and the susceptibility for AICG suggests a role for these cells in maintaining the tolerance against the Fx1A (GP 330) antigen.
Book ChapterDOI
Nephrotisches Syndrom einschließlich renal bedingter Ödeme
TL;DR: Ausdruck Nephrose wird in diesem Zusammenhang immer weniger gebraucht, seit die Arbeiten von Randerath (1935a), Gerard and Cordier (1933), Hein (1938) die Glomerulusveranderungen in den Vordergrund geruckt und gezeigt haben, das die Eiweis-and Lipoidnephrose der Tubuli Nebenerscheinungen ohne nosologische Bedeutung sind.