Journal ArticleDOI
Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions.
TLDR
The small amounts of rat kidney proteins used, support the interpretation that an isoand autosensitization mechanism is at play, and help clarify the mechanism behind the severe nephrotic syndrome noted in 20 rats given Freund's adjuvants and a supernate of rat kidneys suspension by intraperitoneal injection.Abstract:
Summary1) A severe nephrotic syndrome was noted in 20 rats given Freund's adjuvants and a supernate of rat kidney suspension by intraperitoneal injection. When kidney tissue was replaced by liver, only 3 of 21 animals developed a much milder renal disease. Lung or muscle suspensions failed to induce proteinuria in 10 rats. 2) In large doses (0.5 ml) Freund's adjuvants alone produced a mild nephrotic disease in 3 of 10 rats. Even though the smaller amounts of the adjuvants usually used (0.25 ml) never produced proteinuria, slight histological alterations of the glomerular structure were frequently noted. 3) In contradistinction to other tissue suspensions addition of rat kidney supernate enhanced the effect of adjuvants markedly and regularly. 4) The small amounts of rat kidney proteins used, support the interpretation that an isoand autosensitization mechanism is at play.read more
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Journal ArticleDOI
Membranous nephropathy: A ten-year journey of discoveries
Qi Cai,Allen R. Hendricks +1 more
TL;DR: The histopathology of primary MN is discussed, recent revelations regarding pathogenesis, and ancillary tests are revealed.
Journal ArticleDOI
The role of circulating antigen in the formation of immune deposits in experimental membranous nephropathy.
TL;DR: Direct binding of a tubular antigen to a constituent of the glomerulus could initiate in situ immune complex formation, and may explain the variably demonstrable “cross-reactivity” of the Heymann antibody with the glomersular capillary wall.
Journal ArticleDOI
Apical expression of an antigen common to rabbit yolk sac endoderm and kidney proximal tubule epithelium
Timothy J. Meads,Arthur E. Wild +1 more
TL;DR: The tissue distribution, molecular weight, and biochemical nature of an antigen detected by a mouse monoclonal antibody and raised against rabbit visceral yolk sac endodermal cells, has been investigated and has close similarity to Heymann nephritis antigen.
Molecular study of idiopathic nephrotic syndrome
TL;DR: In this article, a panell de gens associats amb malaltia renals com a eina diagnostica per malalties renals quistiques o glomerulars, permetent el diagnostic diferencial d'aquestes malalties, aixi com la identificacio de variants estructurals, mutacions en mosaic i patrons d'herencia complexes.
Journal ArticleDOI
Reabsorption of horseradish peroxidase by proximal tubules in rats with Heymann nephritis.
TL;DR: Functional deficits resulting from immunologic injury to proximal tubules in Heymann nephritis may persist despite waning of the anti-brush border antibody response and regeneration of the brush border of proximaltubule cells.