Journal ArticleDOI
Progesterone receptor membrane component 1--many tasks for a versatile protein.
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TLDR
Current evidence supports the perception that P GRMC1 may be involved in sterol metabolism or homeostasis and cell survival, and unpublished findings on the properties and functions of PGRMC1 are summarized.About:
This article is published in Steroids.The article was published on 2008-10-01. It has received 115 citations till now. The article focuses on the topics: PGRMC1 & Progesterone receptor.read more
Citations
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Cyclic decidualization of the human endometrium in reproductive health and failure.
Birgit Gellersen,Jan J. Brosens +1 more
TL;DR: The endocrine, paracrine, and autocrine cues that tightly govern this differentiation process are reviewed and how disorders that subvert the programming, initiation, or progression of decidualization compromise reproductive health and predispose for pregnancy failure is discussed.
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Genetics of primary ovarian insufficiency: new developments and opportunities
TL;DR: Given the slow progress in candidate-gene analysis and relatively small sample sizes available for GWAS, family-based whole exome and whole genome sequencing appear to be the most promising approaches for detecting potential genes responsible for POI.
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Non-genomic progesterone actions in female reproduction
TL;DR: Convergence and intertwining of rapid non-genomic events and the slower transcriptional actions critically determine the functional response to progesterone in the female reproductive system in a cell-type- and environment-specific manner.
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PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding.
TL;DR: Together with its biological role in promoting tumor survival, PGRMC1 is an attractive target for therapeutic intervention in cancer and related malignancies.
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Rapid Steroid Hormone Actions Initiated at the Cell Surface and the Receptors that Mediate Them with an Emphasis on Recent Progress in Fish Models
TL;DR: Recent results suggest there is cross-talk between these two hormonal pathways and that there is reciprocal down-regulation of GPR30 and mPRα expression by estrogens and progestins at different phases of oocytes development to regulate the onset of oocyte maturation.
References
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Journal ArticleDOI
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Sean A. Beausoleil,Mark P. Jedrychowski,Daniel Schwartz,Joshua E. Elias,Judit Villén,Jiaxu Li,Martin A. Cohn,Lewis C. Cantley,Steven P. Gygi +8 more
TL;DR: Using a strategy based on strong cation exchange chromatography, phosphopeptides were enriched from the nuclear fraction of HeLa cell lysate and determined 2,002 phosphorylation sites, an unprecedented large collection of sites permitted a detailed accounting of known and unknown kinase motifs and substrates.
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Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes
TL;DR: Cloning of a cDNA from spotted seatrout ovaries encoding a protein that satisfies the following seven criteria for its designation as a steroid membrane receptor suggests the fish protein is a membrane progestin receptor mediating a “nonclassical” action of progestins to induce oocyte maturation in fish.
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Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor
TL;DR: The identification, cloning, and characteristics of other members of this hitherto unknown family of putative mPRs from several vertebrate species, including human, mouse, pig, Xenopus, zebrafish, and Fugu, with highly conserved nucleotide and deduced amino acid sequences and similar structures to the spotted seatrout mPR are reported.
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Stress Induction of GRP78/BiP and Its Role in Cancer
Jianze Li,Amy S. Lee +1 more
TL;DR: The transcriptional regulation of Grp78, the molecular basis for the cytoprotective function of GRP78 and its role in cancer progression, drug resistance and potential future cancer therapy are summarized.
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Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells
TL;DR: Two new photoactivatable amino acids are designed based on their structures and properties closely resembling the natural amino acids methionine and leucine, respectively, which allow them to escape the stringent identity control mechanisms during protein synthesis and be incorporated into proteins by the unmodified mammalian translation machinery.