Journal ArticleDOI
Prognostic Nomogram for Intrahepatic Cholangiocarcinoma After Partial Hepatectomy
Yizhou Wang,Jun Li,Yong Xia,Renyan Gong,Kui Wang,Zhenlin Yan,Xuying Wan,Guanghua Liu,Dong Wu,Lehua Shi,Wan Yee Lau,Meng-Chao Wu,Feng Shen +12 more
TLDR
The proposed nomogram resulted in more-accurate prognostic prediction for patients with ICC after partial hepatectomy and was superior to the five currently used staging systems on ICC.Abstract:
Purpose This study aimed to establish an effective prognostic nomogram for intrahepatic cholangiocarcinoma (ICC) after partial hepatectomy. Patients and Methods The nomogram was based on a retrospectively study on 367 patients who underwent partial hepatectomy for ICC at the Eastern Hepatobiliary Surgery Hospital from 2002 to 2007. The predictive accuracy and discriminative ability of the nomogram were determined by concordance index (C-index) and calibration curve and compared with five currently used staging systems on ICC. The results were validated using bootstrap resampling and a prospective study on 82 patients operated on from 2007 to 2008 at the same institution. Results On multivariate analysis of the primary cohort, independent factors for survival were serum carcinoembryonic antigen, CA 19-9, tumor diameter and number, vascular invasion, lymph node metastasis, direct invasion, and local extrahepatic metastasis, which were all selected into the nomogram. The calibration curve for probability of ...read more
Citations
More filters
Journal ArticleDOI
Cholangiocarcinoma 2020: the next horizon in mechanisms and management
Jesus M. Banales,Jesus M. Banales,Jesus M. Banales,Jose J.G. Marin,Jose J.G. Marin,Angela Lamarca,Angela Lamarca,Pedro M. Rodrigues,Shahid A. Khan,Lewis R. Roberts,Vincenzo Cardinale,Guido Carpino,Jesper B. Andersen,Chiara Braconi,Diego F. Calvisi,Maria J. Perugorria,Maria J. Perugorria,Luca Fabris,Luca Fabris,Luke Boulter,Rocio I.R. Macias,Rocio I.R. Macias,Eugenio Gaudio,Domenico Alvaro,Sergio A. Gradilone,Mario Strazzabosco,Mario Strazzabosco,Marco Marzioni,Cédric Coulouarn,Laura Fouassier,Chiara Raggi,Pietro Invernizzi,Joachim C. Mertens,Anja Moncsek,Sumera Rizvi,Julie K. Heimbach,Bas Groot Koerkamp,Jordi Bruix,Jordi Bruix,Alejandro Forner,Alejandro Forner,John Bridgewater,Juan W. Valle,Juan W. Valle,Gregory J. Gores +44 more
TL;DR: This expert Consensus Statement, endorsed by the ENS-CCA, summarizes the latest advances in CCA, including classification, genetics and treatment, and provides recommendations for CCA management and priorities across basic, translational and clinical research.
Journal ArticleDOI
Treatment and Prognosis for Patients With Intrahepatic Cholangiocarcinoma Systematic Review and Meta-analysis
TL;DR: The outcomes of the study were overall survival and recurrence-free survival and the prognosis of ICC is dictated mainly by tumor factors, which could focus on the usefulness of adjuvant treatment as well as other multidisciplinary treatment modalities.
Journal ArticleDOI
Development and Validation of a Nomogram for Predicting Survival in Patients With Resected Non–Small-Cell Lung Cancer
Wenhua Liang,Li Zhang,Gening Jiang,Qun Wang,Lunxu Liu,Deruo Liu,Zheng Wang,Zhihua Zhu,Qiuhua Deng,Xinguo Xiong,Wenlong Shao,Xiaoshun Shi,Jianxing He +12 more
TL;DR: A novel nomogram is established and validated that can provide individual prediction of OS for patients with resected NSCLC and may help clinicians in decision making and design of clinical studies.
Journal ArticleDOI
New Horizons for Precision Medicine in Biliary Tract Cancers
TL;DR: A state-of-the-art update of the current status and future directions of research and therapy in advanced biliary tract cancers is described, addressing genetic drivers and molecular biology from a translational perspective.
Journal ArticleDOI
Cholangiocarcinoma: Current Knowledge and New Developments
TL;DR: The changing epidemiologic trends and an overview of newly identified etiologic risk factors for CCA are discussed and the molecular pathogenesis is discussed as well as the influence of etiology and biliary location on the mutational landscape of CCA.
References
More filters
Book
AJCC Cancer Staging Manual
Mahul B. Amin,Stephen B. Edge,Frederick L. Greene,David R. Byrd,Robert K. Brookland,Mary Kay Washington,Jeffrey E. Gershenwald,Carolyn C. Compton,Kenneth R. Hess,Daniel C. Sullivan,J. Milburn Jessup,James D. Brierley,Lauri E. Gaspar,Richard L. Schilsky,Charles M. Balch,David P. Winchester,Elliot A. Asare,Martin Madera,Donna M. Gress,Laura R. Meyer +19 more
TL;DR: Purposes and Principles of Cancer Staging and End-Results Reporting are explained.
Journal ArticleDOI
Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors
TL;DR: In this article, an easily interpretable index of predictive discrimination as well as methods for assessing calibration of predicted survival probabilities are discussed, which are particularly needed for binary, ordinal, and time-to-event outcomes.
Book ChapterDOI
Prognostic/Clinical Prediction Models: Multivariable Prognostic Models: Issues in Developing Models, Evaluating Assumptions and Adequacy, and Measuring and Reducing Errors
TL;DR: An easily interpretable index of predictive discrimination as well as methods for assessing calibration of predicted survival probabilities are discussed, applicable to all regression models, but are particularly needed for binary, ordinal, and time-to-event outcomes.
Journal ArticleDOI
Prognosis of hepatocellular carcinoma : the bclc staging classification
TL;DR: A new staging system is proposed, the Barcelona Clinic Liver Cancer (BCLC) staging classification, that comprises four stages that select the best candidates for the best therapies currently available, based on prognostic factors obtained from studies performed years ago.
Journal ArticleDOI
The epidemiology of cholangiocarcinoma.
TL;DR: Some data point to a potential role for chronic liver disease, hepatitis C, and probably hepatitis B infections in the development of ICC, as well as the recent increasing trends of ICC in the United States.