Journal ArticleDOI
Progression to end-stage liver disease in patients with inherited bleeding disorders and hepatitis C: an international, multicenter cohort study.
Dirk Posthouwer,Michael Makris,Thynn Thynn Yee,Krista Fischer,Joost J. van Veen,Anja Griffioen,Karel J. van Erpecum,Eveline P. Mauser-Bunschoten +7 more
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TLDR
With longer duration of HCV infection, the risk of developing ESLD is emerging in patients with inherited bleeding disorders and risk factors for rapid progression are alcohol abuse, coinfection with HIV, older age at infection, and presence ofHCV genotype 1.About:
This article is published in Blood.The article was published on 2007-05-01. It has received 86 citations till now. The article focuses on the topics: Coinfection & Hepatitis C.read more
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Journal ArticleDOI
How I treat age-related morbidities in elderly persons with hemophilia
Pier Mannuccio Mannucci,Roger E. G. Schutgens,Elena Santagostino,Evelien P. Mauser-Bunschoten +3 more
TL;DR: More detailed advice is provided on the schedules of replacement therapy needed to tackle cardiovascular diseases, such as acute coronary syndromes and nonvalvular atrial fibrillation, because these conditions will become more and more frequent challenges for the comprehensive treatment centers.
Journal ArticleDOI
Co‐morbidity in the ageing haemophilia patient: the down side of increased life expectancy
TL;DR: It is reported that haemophilia seems to protect against cardiovascular disease, although the incidence is increasing, and co‐morbidity has a major psychological impact, and an important effect on quality of life.
Journal ArticleDOI
Co‐morbidities and quality of life in elderly persons with haemophilia
TL;DR: This review focuses on co‐morbidities in the ageing haemophilia patients, their impact on quality of life and their complex management.
Journal ArticleDOI
Consensus conference on TIPS management: Techniques, indications, contraindications.
Stefano Fagiuoli,Raffaele Bruno,Wilma Debernardi Venon,Filippo Schepis,Francesco Vizzutti,Pierluigi Toniutto,Marco Senzolo,Paolo Caraceni,Francesco Salerno,Paolo Angeli,Roberto Cioni,Alessandro Vitale,Maurizio Grosso,Andrea De Gasperi,Gennaro D'Amico,Alfredo Marzano +15 more
TL;DR: The trans jugular intrahepatic Porto systemic shunt (TIPS) is no longer viewed as a salvage therapy or a bridge to liver transplantation and is currently indicated for a number of conditions related to portal hypertension with positive results in survival.
Journal ArticleDOI
The aging patient with hemophilia: complications, comorbidities, and management issues.
TL;DR: In this article, the authors developed evidence-based guidelines for the older hemophilia population, which is anticipated to expand in the future, by using registry databases and cooperative group studies.
References
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Journal ArticleDOI
Hepatitis C Virus Infection
Georg M. Lauer,Bruce D. Walker +1 more
TL;DR: The institution of blood-screening measures in developed countries has decreased the risk of transfusion-associated hepatitis to a negligible level, but new cases continue to occur mainly as a result of injection-drug use and, to a lesser degree, through other means of percutaneous or mucous-membrane exposure.
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Prospective Comparison of Transient Elastography, Fibrotest, APRI, and Liver Biopsy for the Assessment of Fibrosis in Chronic Hepatitis C
Laurent Castera,Julien Vergniol,Juliette Foucher,Brigitte Le Bail,E. Chanteloup,Maud Haaser,Monique Darriet,Patrice Couzigou,Victor de Ledinghen +8 more
TL;DR: FibroScan is a simple and effective method for assessing liver fibrosis, with similar performance to FibroTest and APRI, and could avoid a biopsy procedure in most patients with chronic hepatitis C.
Journal ArticleDOI
Natural history of chronic hepatitis C
TL;DR: Efforts to determine natural history are handicapped by the primary characteristics of the disease, namely that its onset rarely is recognized and its course is prolonged exceedingly, so that at least 20% of chronically infected adults develop cirrhosis within 20 years.
Journal ArticleDOI
Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C.
Marianne Ziol,Adriana Handra-Luca,Adrien Kettaneh,Christos Christidis,F. Mal,F. Kazemi,Victor de Ledinghen,Patrick Marcellin,Daniel Dhumeaux,Jean-Claude Trinchet,Michel Beaugrand +10 more
TL;DR: Noninvasive assessment of liver stiffness with transient elastography appears as a reliable tool to detect significant fibrosis or cirrhosis in patients with chronic hepatitis C.
Journal ArticleDOI
Molecular Biology of Aging
TL;DR: This work presents a meta-anatomy of Aging and its role in Age-related Diseases through the lens of Mitochondrion, which describes the role of mitochondria in the building and breaking down of age-related diseases.