Prolactin Receptor Gene Polymorphisms Are Associated with Gestational Diabetes
Trang N. Le,Sarah H. Elsea,Roberto Romero,Tinnakorn Chaiworapongsa,Tinnakorn Chaiworapongsa,Gary L. Francis +5 more
TLDR
SNPs of the PRLR gene 5' UTR and promoter region are associated with increased risk for GDM in a population of Chilean subjects.Abstract:
Aims: Human placental lactogen (hPL) acts via the prolactin receptor (PRLR) on maternal β-cells to mediate increases in β-cell mass and function during normal pregnancy. This interaction between hPL and PRLR is essential to maintain normal glucose homeostasis and to address the increased metabolic demands of pregnancy. Given the importance of the PRLR-hPL axis in pancreatic islet cell adaptation to pregnancy, we hypothesized that genetic variation in the PRLR gene could influence risk of development of gestational diabetes mellitus (GDM). DNA samples from 96 mothers affected by GDM and 96 unaffected cases were genotyped for 8 selected single nucleotide polymorphisms (SNPs) in PRLR. Results: Significant associations were identified in two SNPs analyzed. The minor alleles of PRLR SNPs rs10068521 and rs9292578 were more frequently observed in GDM cases than controls and were associated with a 2.36-fold increased risk for GDM in those carrying the minor allele. Conclusion: SNPs of the PRLR gene 5′ UTR and promoter region are associated with increased risk for GDM in a population of Chilean subjects.read more
Citations
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Journal ArticleDOI
The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation
TL;DR: The changes that occur in maternal physiology in response to pregnancy and the significance of placental hormone production in mediating such changes are examined.
Journal ArticleDOI
Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells
Ronadip R. Banerjee,Holly A. Cyphert,Emily M. Walker,Harini Chakravarthy,Heshan Peiris,Xueying Gu,Yinghua Liu,Elizabeth Conrad,Lisa V. Goodrich,Roland Stein,Seung K. Kim +10 more
TL;DR: It is shown that loss of PRLR signaling in β-cells results in gestational diabetes mellitus (GDM), reduced β- cell proliferation, and failure to expand β-cell mass during pregnancy.
Journal ArticleDOI
Biological underpinnings of breastfeeding challenges: the role of genetics, diet, and environment on lactation physiology.
Sooyeon Lee,Shannon L. Kelleher +1 more
TL;DR: An overview of the current understanding of the role of maternal genetics and modifiable factors, such as diet and environmental exposures, on reproductive endocrinology, lactation physiology, and the ability to successfully produce milk is provided.
Journal ArticleDOI
Predictive and diagnostic biomarkers for gestational diabetes and its associated metabolic and cardiovascular diseases.
Ana Lorenzo-Almorós,T. Hang,Concepción Peiró,Leandro Soriano-Guillén,Jesús Egido,José Tuñón,Óscar Lorenzo +6 more
TL;DR: 1st–2nd trimester-released biomarkers found in maternal plasma including adipose tissue-derived factors such as adiponectin, visfatin, omentin-1, fatty acid-binding protein-4 and retinol binding-protein-4 have shown correlations with GDM development, which may complete a predictive or early-diagnostic panel of biomarkers for GDM.
Journal ArticleDOI
Advancements and challenges in generating accurate animal models of gestational diabetes mellitus
Raymond C. Pasek,Maureen Gannon +1 more
TL;DR: The various animal models that have been generated to better understand the etiology of diabetes during pregnancy and its physiological impacts on both the mother and the fetus are discussed and critique.
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What can we learn from rodents about prolactin in humans
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