Proposal for a unified classification system and nomenclature of lagoviruses.
Jacques Le Pendu,Joana Abrantes,Stéphane Bertagnoli,Jean Sébastien Guitton,Ghislaine Le Gall-Reculé,Ana M. Lopes,Stéphane Marchandeau,Fernando Alda,Tereza Almeida,Alves Paulo Célio,Alves Paulo Célio,Juan Bárcena,Galina Burmakina,Esther Blanco,Carlos Calvete,Patrizia Cavadini,Brian Cooke,Kevin P. Dalton,Miguel Delibes Mateos,Wiesław Deptuła,John-Sebastian Eden,Fang Wang,Catarina Ferreira,Catarina Ferreira,Paula G. Ferreira,Pilar Foronda,David Gonçalves,Dolores Gavier-Widén,Robin Hall,Beata Hukowska-Szematowicz,Peter J. Kerr,John Kovaliski,Antonio Lavazza,Jackie E. Mahar,Jackie E. Mahar,Alexander Malogolovkin,Raquel M. Marques,Sara Marques,Aarón Martin-Alonso,Pedro Monterroso,Sacramento Moreno,Greg Mutze,Aleksija Neimanis,Paulina Niedzwiedzka-Rystwej,David Peacock,Francisco Parra,Mara Rocchi,Carlos Rouco,Nathalie Ruvoën-Clouet,Eliane Silva,Diogo Silvério,Tanja Strive,Gertrudes Thompson,Beata Tokarz-Deptuła,Pedro J. Esteves +54 more
TLDR
It is proposed that an international working group could coordinate the nomenclature of lagoviruses and any proposals for revision and be divided into two genogroups that correspond to RHDV- and EBHSV-related viruses, respectively.Abstract:
Lagoviruses belong to the Caliciviridae family. They were first recognized as highly pathogenic viruses of the European rabbit (Oryctolagus cuniculus) and of the European brown hare (Lepus europaeus) that emerged in the 1970-1980s, namely, rabbit hemorrhagic disease virus (RHDV) and European brown hare syndrome virus (EBHSV), according to the host species from which they had been first detected. However, the diversity of lagoviruses has recently expanded to include new related viruses with varying pathogenicity, geographic distribution and host ranges. Together with the frequent recombination observed amongst circulating viruses, there is a clear need to establish precise guidelines for classifying and naming lagovirus strains. Therefore, here we propose a new nomenclature based on phylogenetic relationships. In this new nomenclature a single species of lagovirus would be recognized and called Lagovirus europaeus. The species would be divided into two genogroups that correspond to RHDV- and EBHSV-related viruses, respectively. Genogroups could be subdivided into genotypes, which could themselves be subdivided into phylogenetically well-supported variants. Based on available sequences, pairwise distance cutoffs have been defined, but with the accumulation of new sequences these cutoffs may need to be revised. We propose that an international working group could coordinate the nomenclature of lagoviruses and any proposals for revision.read more
Citations
More filters
Journal ArticleDOI
Rabbit Hemorrhagic Disease Virus 2 (RHDV2; GI.2) Is Replacing Endemic Strains of RHDV in the Australian Landscape within 18 Months of Its Arrival
Jackie E. Mahar,Jackie E. Mahar,Robyn N. Hall,Robyn N. Hall,David Peacock,John Kovaliski,Melissa Piper,Roslyn G. Mourant,Nina Huang,Susan Campbell,Xingnian Gu,AJ Read,Nadya Urakova,Nadya Urakova,Nadya Urakova,Tarnya E. Cox,Edward C. Holmes,Tanja Strive +17 more
TL;DR: Reconstruction of the evolutionary history of 127 Australian GI.2 isolates revealed that the virus arrived in Australia at least several months before its initial description and likely circulated unnoticed in wild rabbit populations in the east of the continent prior to its detection.
Journal ArticleDOI
Elucidation of the pathology and tissue distribution of Lagovirus europaeus GI.2/RHDV2 (rabbit haemorrhagic disease virus 2) in young and adult rabbits (Oryctolagus cuniculus).
Aleksija Neimanis,Aleksija Neimanis,Ulrika Larsson Pettersson,Nina Huang,Dolores Gavier-Widén,Dolores Gavier-Widén,Tanja Strive +6 more
TL;DR: The first detailed description of pathology, viral antigen distribution and tissue load of GI.2 in adult and 5-week old New Zealand white rabbits is provided, and the first descriptions of bone marrow changes in RHD, including decreased myeloid-to-erythroid ratio are presented.
Journal ArticleDOI
Insights into the evolution of the new variant rabbit haemorrhagic disease virus (GI.2) and the identification of novel recombinant strains
Diogo Silvério,Ana M. Lopes,José Melo-Ferreira,Maria J. Magalhães,Pedro Monterroso,Ana Serronha,E. Maio,Paulo C. Alves,Paulo C. Alves,Pedro J. Esteves,Joana Abrantes +10 more
TL;DR: This is the first study on GI.2 evolution and highlights the need of continued monitoring and characterization of complete genome sequences when studying lagoviruses' evolution by sequencing full genomes of 19 samples collected in Portugal between 2014 and 2016.
Journal ArticleDOI
Large-scale lagovirus disease outbreaks in European brown hares ( Lepus europaeus ) in France caused by RHDV2 strains spatially shared with rabbits ( Oryctolagus cuniculus )
Ghislaine Le Gall-Reculé,Evelyne Lemaitre,Stéphane Bertagnoli,Céline Hubert,Sokunthea Top,Anouk Decors,Stéphane Marchandeau,Jean-Sébastien Guitton +7 more
TL;DR: It is shown that R HDV2 is widely distributed in France and that it was responsible for more than a third of cases of lagovirus disease in European hare populations in 2015, and the enlargement of the host range changes the host population structure of RHDV2 and may alter the impact of the virus on rabbit and hares populations.
Journal ArticleDOI
A strain-specific multiplex RT-PCR for Australian rabbit haemorrhagic disease viruses uncovers a new recombinant virus variant in rabbits and hares.
Robyn N. Hall,Robyn N. Hall,Jackie E. Mahar,Jackie E. Mahar,AJ Read,Roslyn G. Mourant,Melissa Piper,Nina Huang,Tanja Strive,Tanja Strive +9 more
TL;DR: A highly sensitive strain-specific multiplex RT-PCR assay was developed, which allows fast, cost-effective and sensitive detection of the four pathogenic lagoviruses currently known to be circulating in Australia and a novel recombinant lagovirus was detected in rabbit tissue samples.
References
More filters
Journal ArticleDOI
MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0
TL;DR: An advanced version of the Molecular Evolutionary Genetics Analysis software, which currently contains facilities for building sequence alignments, inferring phylogenetic histories, and conducting molecular evolutionary analysis, is released, which enables the inference of timetrees, as it implements the RelTime method for estimating divergence times for all branching points in a phylogeny.
Brief Communication MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0
TL;DR: The Molecular Evolutionary Genetics Analysis (MEGA) software as discussed by the authors provides facilities for building sequence alignments, inferring phylogenetic histories, and conducting molecular evolutionary analysis, including the inference of timetrees.
Journal ArticleDOI
Proposal for a unified norovirus nomenclature and genotyping.
Annelies Kroneman,Everardo Vega,Harry Vennema,Jan Vinjé,Peter A. White,Grant S. Hansman,Kim Y. Green,Kim Y. Green,Vito Martella,Kazuhiko Katayama,Marion Koopmans +10 more
TL;DR: It is demonstrated that the pairwise distance cutoff method can no longer be used and a phylogenetic approach to classify noroviruses is outlined and a dual nomenclature using both ORF1 and VP1 sequences is proposed, as recombination is common and recognizing recombinant viruses may be relevant.
Journal ArticleDOI
Rabbit haemorrhagic disease (RHD) and rabbit haemorrhagic disease virus (RHDV): a review.
TL;DR: Although the study of RHDV and RHD has been hampered by the lack of an appropriate cell culture system for the virus, several aspects of the replication, epizootology, epidemiology and evolution have been disclosed.
Related Papers (5)
Emergence of a new lagovirus related to Rabbit Haemorrhagic Disease Virus
Ghislaine Le Gall-Reculé,Ghislaine Le Gall-Reculé,Antonio Lavazza,Stéphane Marchandeau,Stéphane Bertagnoli,F. Zwingelstein,F. Zwingelstein,Patrizia Cavadini,Nicola Martinelli,Guerino Lombardi,Jean-Luc Guérin,Evelyne Lemaitre,Evelyne Lemaitre,Anouk Decors,Samuel Boucher,Bernadette Le Normand,Lorenzo Capucci +16 more