Journal ArticleDOI
Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers.
TLDR
Prussian blue nanoparticles (PBNPs) can effectively scavenge ROS via multienzyme-like activity including peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) activity and are shown to be POD mimetics that can inhibit •OH generation.Abstract:
The generation of reactive oxygen species (ROS) is an important mechanism of nanomaterial toxicity. We found that Prussian blue nanoparticles (PBNPs) can effectively scavenge ROS via multienzyme-like activity including peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) activity. Instead of producing hydroxyl radicals (•OH) through the Fenton reaction, PBNPs were shown to be POD mimetics that can inhibit •OH generation. We theorized for the first time that the multienzyme-like activities of PBNPs were likely caused by the abundant redox potentials of their different forms, making them efficient electron transporters. To study the ROS scavenging ability of PBNPs, a series of in vitro ROS-generating models was established using chemicals, UV irradiation, oxidized low-density lipoprotein, high glucose contents, and oxygen glucose deprivation and reperfusion. To demonstrate the ROS scavenging ability of PBNPs, an in vivo inflammation model was established using lipoproteins in Institute for Cance...read more
Citations
More filters
Journal ArticleDOI
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
TL;DR: This review systematically introduces the classification, catalytic mechanism, activity regulation as well as recent research progress of nanozymes in the field of biosensing, environmental protection, and disease treatments, etc. in the past years.
Journal ArticleDOI
Reactive Oxygen Species (ROS)-Based Nanomedicine.
Bowen Yang,Yu Chen,Jianlin Shi +2 more
TL;DR: In this article, the intrinsic biochemical properties of reactive oxygen species (ROS) underlie the mechanisms that regulate various physiological functions of living organisms, and they play an essential role in regulating various physiological function.
Journal ArticleDOI
Nanozyme: new horizons for responsive biomedical applications.
TL;DR: By integrating the catalytic property and inherent nanomaterial nature of nanozyme systems, it is anticipated that stimuli-responsive nanozymes will open up new horizons for diagnosis, treatment, and theranostics.
Journal ArticleDOI
Surface-Enhanced Raman Scattering Active Gold Nanoparticles with Enzyme-Mimicking Activities for Measuring Glucose and Lactate in Living Tissues
Yihui Hu,Hanjun Cheng,Xiaozhi Zhao,Jiangjiexing Wu,Faheem Muhammad,Shichao Lin,Jian He,Liqi Zhou,Chengping Zhang,Yu Deng,Peng Wang,Zhengyang Zhou,Shuming Nie,Shuming Nie,Hui Wei +14 more
TL;DR: The integrative nanozymes of AuNPs were used to evaluate the therapeutic efficacy of potential drugs and determine glucose and lactate metabolism in tumors and provided an interesting approach to designing nanoZymes for biomedical and catalytic applications.
Journal ArticleDOI
Hollow Structures Based on Prussian Blue and Its Analogs for Electrochemical Energy Storage and Conversion.
Jianwei Nai,Xiong Wen David Lou +1 more
TL;DR: The research of Prussian blue and its analog (PBA) related nanomaterials has emerged and has drawn considerable attention because of their low cost, facile preparation, intrinsic open framework, and tunable composition.
References
More filters
Journal ArticleDOI
Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
Lizeng Gao,Jie Zhuang,Leng Nie,Jinbin Zhang,Yu Zhang,Ning Gu,Taihong Wang,Jing Feng,Dongling Yang,Sarah Perrett,Xiyun Yan +10 more
TL;DR: It is reported that magnetite nanoparticles in fact possess an intrinsic enzyme mimetic activity similar to that found in natural peroxidases, which are widely used to oxidize organic substrates in the treatment of wastewater or as detection tools.
Journal ArticleDOI
The role of cerium redox state in the SOD mimetic activity of nanoceria
TL;DR: X-ray photoelectron spectroscopy and UV-visible analyses of nanoceria treated with hydrogen peroxide demonstrate that a decrease in the Ce 3(+)/4(+) ratio correlates directly with a loss of SOD mimetic activity.
Journal ArticleDOI
Prussian Blue and Its Analogues: Electrochemistry and Analytical Applications
TL;DR: In this article, fundamental aspects of deposition, structure and electrochemistry of Prussian Blue and its analogues are discussed, and the future prospects of chemical and biological sensors based on metal hexacyanoferrates are outlined.
Journal ArticleDOI
Electrochemistry of polynuclear transition metal cyanides: Prussian blue and its analogues
Journal ArticleDOI
Dual Enzyme-like Activities of Iron Oxide Nanoparticles and Their Implication for Diminishing Cytotoxicity
TL;DR: It is reported that different intracellular microenvironment in which IONPs are located leads to contradictive outcomes in their abilities to produce free radicals, and lysosome-escaped strategy for IONP delivery would be an efficient way to diminish long-term toxic potential.
Related Papers (5)
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
Hui Wei,Erkang Wang +1 more