Psychological symptoms and subsequent healthy lifestyle after a colorectal cancer diagnosis.
Claudia Trudel-Fitzgerald,Shelley S. Tworoger,Elizabeth M. Poole,Xuehong Zhang,Edward Giovannucci,Jeffrey A. Meyerhardt,Laura D. Kubzansky +6 more
TLDR
Among women with CRC, higher anxiety and depression symptoms were associated with subsequent unhealthier lifestyle in the 10 years following diagnosis, which may suggest that treating psychological symptoms early in the cancer trajectory may not solely reduce psychological distress but also promote healthier lifestyle.Abstract:
Objective Although medical professionals recommend lifestyle changes following a colorectal cancer (CRC) diagnosis to improve outcomes, such changes are not consistently implemented. This study examines whether higher distress is associated with lower likelihood of engaging in favorable behaviors after CRC diagnosis. Method Women from the Nurses' Health Study prospective cohort who completed anxiety (n = 145) and depression (n = 227) symptom scales within 4 years after receiving a CRC diagnosis were included. Measures of lifestyle (diet, physical activity, alcohol, smoking, body mass index [BMI]) were queried prediagnosis, when psychological symptoms were assessed (1988 and 1992, respectively), and then every 4 years thereafter until 2010. Women were categorized according to initial psychological symptoms levels and followed through 2010 or until last follow-up completed. Results Higher versus lower anxiety symptoms were significantly related to unhealthier lifestyle scores throughout follow-up (β = -0.25, CI [-0.44, -0.05]); however, the rate of change over time was similar across groups (pinteraction effect = 0.41). Stratified analyses hinted that higher anxiety and depression symptoms were related to increased odds of reporting a future unhealthy lifestyle within 10-years postdiagnosis. Beyond 10 years, anxiety became statistically unrelated with future lifestyle, and higher depressive symptoms were associated with lower odds of subsequently having an unhealthy lifestyle, albeit nonstatistically significant (OR = 0.35, 95% CI [0.10, 1.24], p = 0.10). Conclusions Among women with CRC, higher anxiety and depression symptoms were associated with subsequent unhealthier lifestyle in the 10 years following diagnosis. With replication, such findings may suggest that treating psychological symptoms early in the cancer trajectory may not solely reduce psychological distress but also promote healthier lifestyle. (PsycINFO Database Recordread more
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Reproducibility and validity of a self-administered physical activity questionnaire for male health professionals.
Scott Chasan-Taber,Eric B. Rimm,Meir J. Stampfer,Donna Spiegelman,Graham A. Colditz,Edward Giovannucci,Alberto Ascherio,Walter C. Willett +7 more
TL;DR: In this article, the reproducibility and validity of a self-administered physical activity questionnaire used in a prospective study of 51,529 men was assessed, and the questionnaire was administered by mail twice to 238 participants 2 years apart.
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Symptom Experiences in Colorectal Cancer Survivors After Cancer Treatments: A Systematic Review and Meta-analysis.
TL;DR: Colorectal cancer survivors experienced multiple adverse symptoms related to distinct risk factors, which negatively impacted patients and caregivers' well-being and healthcare providers can use study findings to better assess and monitor patient symptoms after cancer treatments.
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Prospective associations of happiness and optimism with lifestyle over up to two decades.
Claudia Trudel-Fitzgerald,Peter James,Eric S. Kim,Emily S. Zevon,Francine Grodstein,Laura D. Kubzansky +5 more
TL;DR: While bidirectional associations are apparent, these findings suggest pursuing happiness and optimism as modifiable determinants of lifestyle deserves further consideration.
Journal ArticleDOI
Anxiety, Depression, and Colorectal Cancer Survival: Results from Two Prospective Cohorts.
Claudia Trudel-Fitzgerald,Shelley S. Tworoger,Xuehong Zhang,Xuehong Zhang,Edward Giovannucci,Jeffrey A. Meyerhardt,Laura D. Kubzansky +6 more
TL;DR: The findings suggest greater anxiety and depression symptoms can not only impede adherence to healthy habits and reduce quality of life in cancer patients but could also be a marker for accelerated CRC progression.
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Circular RNA circ_0000372 contributes to the proliferation, migration and invasion of colorectal cancer by elevating IL6 expression via sponging miR-495.
TL;DR: In this article, the expression of circ_0000372 and microRNA (miR)-495 was examined by quantitative real-time PCR cell proliferation was evaluated using cell counting kit 8 and colony formation assays Further, cell migration and invasion were assessed using transwell assay.
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