Journal ArticleDOI
PyBOP®: A new peptide coupling reagent devoid of toxic by-product
TLDR
PyBOP as discussed by the authors, an analog of BOP where dimethylamino groups are replaced with pyrrolidino, is the only analog exhibiting equivalent properties in peptide bond formation.About:
This article is published in Tetrahedron Letters.The article was published on 1990-01-01. It has received 596 citations till now. The article focuses on the topics: PyBOP & Peptide bond.read more
Citations
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Amide bond formation: beyond the myth of coupling reagents
Eric Valeur,Mark Bradley +1 more
TL;DR: This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the plethora of "acronym" based reagents.
Journal ArticleDOI
Amide bond formation and peptide coupling
TL;DR: In this article, the authors propose a method to solve the problem of "uniformity" in the literature: 1.0040−4020/$ doi:10.1016/
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Synthetic therapeutic peptides: science and market.
TL;DR: This review reports on the unexpected and considerable number of peptides that are currently available as drugs and the chemical strategies that were used to bring them into the market.
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Chemical Synthesis of Natural Product Peptides: Coupling Methods for the Incorporation of Noncoded Amino Acids into Peptides.
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Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
Dean G. Brown,Jonas Boström +1 more
TL;DR: It is shown that current practices result in overpopulation of certain types of molecular shapes to the exclusion of others using simple PMI plots, which could help catalyze improvements in integration of new synthetic methodologies as well as new library design.
References
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Journal ArticleDOI
New coupling reagents in peptide chemistry
TL;DR: A general synthetic procedure for new derivatives of different N-hydroxy compounds has been developed and these either act as excellent activating reagents causing low racemization during condensation of peptide segments or are useful tools for the formation of active esters suitable for couplings in mixed aqueous / organic media, respectively.
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Reactifs de couplage peptidique I (1) - l'hexafluorophosphate de benzotriazolyl N-oxytrisdimethylamino phosphonium (B.O.P.)
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N,N'-Carbonyldiimidazole, a New Peptide Forming Reagent1
Rolf Paul,George W. Anderson +1 more