Journal ArticleDOI
Quality-of-life changes in patients with thyroid cancer after withdrawal of thyroid hormone therapy.
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TLDR
The QOL-Thyroid tool is a reliable and valid measure for use in evaluating patients undergoing scanning procedures and may be used to identify and target teaching and support for high-risk areas in patients lives that are negatively affected by hormone withdrawal.Abstract:
Quality of life (QOL) is an important consideration as patients survive longer with cancer and is an area of increasing interest in patients with thyroid cancer who undergo long-term cancer surveillance. However, there are few disease-specific QOL tools available to evaluate QOL in patients with thyroid cancer. The purposes of this longitudinal, repeated-measures study were to: (1) test a new instrument, the QOL-Thyroid Scale, during thyroid hormone withdrawal; and (2) to evaluate the impact of thyroid hormone withdrawal on patients' perceived changes in quality of life. The sample included 34 subjects (mean age 40 years) undergoing thyroid hormone withdrawal in preparation for scanning procedures. Subjects completed three instruments (demographic data tool, the QOL-Thyroid, and the FACT-G) at four specific time points in relationship to scanning. The results demonstrated that the QOL-Thyroid tool is a reliable and valid measure of QOL. Cronbach's alpha coefficient of r = .78 between QOL-Thyroid and FACT-G indicated good concurrent validity. Second, the impact of thyroid hormone withdrawal on QOL showed significant changes in physical, psychological, and social well-being across the four testing points. The greatest changes occurred between peak hormone withdrawal and thyroxine (T4) therapy. While it is generally known that patients suffer troublesome physical symptoms relating to thyroid hormone withdrawal, the negative psychological, family, and work sequelae are less apparent. In conclusion, the QOL-Thyroid is a reliable and valid measure for use in evaluating patients undergoing scanning procedures and may be used to identify and target teaching and support for high-risk areas in patients lives that are negatively affected by hormone withdrawal.read more
Citations
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Journal ArticleDOI
Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement
Jacqueline Jonklaas,Antonio C. Bianco,Andrew J. Bauer,Kenneth D. Burman,Anne R. Cappola,Francesco S. Celi,David S. Cooper,Brian W. Kim,Robin P. Peeters,M. Sara Rosenthal,Anna M. Sawka +10 more
TL;DR: It is concluded that levothyroxine should remain the standard of care for treating hypothyroidism and no consistently strong evidence for the superiority of alternative preparations is found.
Journal ArticleDOI
Guidelines for radioiodine therapy of differentiated thyroid cancer
Markus Luster,S. E. Clarke,Markus Dietlein,Michael Lassmann,P. Lind,Wim J.G. Oyen,Jan Tennvall,Emilio Bombardieri +7 more
TL;DR: Recommendations are provided on pre-RAIT history and examinations, patient counselling and precautions that should be associated with 131I iodine ablation and treatment, and potential side effects of radioiodine therapy and alternate or additional treatments to this modality are reviewed.
Journal ArticleDOI
A comparison of recombinant human thyrotropin and thyroid hormone withdrawal for the detection of thyroid remnant or cancer.
Bryan R. Haugen,Furio Pacini,Christoph Reiners,Martin Schlumberger,Paul W. Ladenson,Steven I. Sherman,David S. Cooper,Kathryn E. Graham,Lewis E. Braverman,Monica C. Skarulis,Terry F. Davies,Leslie J. DeGroot,Ernest L. Mazzaferri,Gilbert H. Daniels,Douglas S. Ross,Markus Luster,Mary H. Samuels,David V. Becker,Harry R. Maxon,Ralph R. Cavalieri,Carole A. Spencer,Kevin McEllin,Bruce D. Weintraub,E. Chester Ridgway +23 more
TL;DR: Comparing the effect of administered recombinant TSH with thyroid hormone withdrawal on the results of radioiodine whole body scanning (WBS) and serum thyroglobulin (Tg) levels found recombinant human TSH administration is a safe and effective means of stimulatingRadioiodine uptake and serum Tg levels in patients undergoing evaluation for thyroid cancer persistence and recurrence.
Journal ArticleDOI
Radioiodine ablation of thyroid remnants after preparation with recombinant human thyrotropin in differentiated thyroid carcinoma: results of an international, randomized, controlled study.
Furio Pacini,Furio Pacini,Pw Ladenson,Martin Schlumberger,Al Driedger,Markus Luster,Rt Kloos,Steven I. Sherman,Bryan R. Haugen,C. Corone,Eleonora Molinaro,Rossella Elisei,C Ceccarelli,Aldo Pinchera,Rl Wahl,Sophie Leboulleux,Marcel Ricard,J Yoo,Nl Busaidy,E Delpassand,Heribert Hänscheid,R. Felbinger,Michael Lassmann,Chr. Reiners +23 more
TL;DR: This study demonstrates comparable remnant ablation rates in patients prepared for 131I remnantAblation with 3.7 GBq by either administering rhTSH or withholding thyroid hormone, and maintains a higher quality of life and received less radiation exposure to the blood.
Journal ArticleDOI
Follow-up of low-risk patients with differentiated thyroid carcinoma: a European perspective.
Martin Schlumberger,Gertrud Berg,Ohad Cohen,Leonidas H. Duntas,François Jamar,Barbara Jarzab,Eduard Limbert,Peter Lind,Furio Pacini,Christoph Reiners,Franco Sanchez Franco,Anthony Toft,Wilmar M. Wiersinga +12 more
TL;DR: A revised follow-up protocol for low-risk patients with DTC is presented to help clinicians enter a new era of monitoring characterized by greater safety, simplicity, convenience and cost savings.
References
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Journal ArticleDOI
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Journal ArticleDOI
Thyroid Cancer: A Lethal Endocrine Neoplasm
John A Robbins,Maria J. Merino,J.D. Boice,E. Ron,K.B. Ain,H R Alexander,Jeffrey A. Norton,James C. Reynolds +7 more
TL;DR: This conference focuses on the controversies about managing thyroid cancer, emphasizing the possibility that the treatment of patients with potentially fatal thyroid cancer may be improved and possible ways to increase the effectiveness of radioiodine therapy are considered.
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