Rad51 Protein Controls Rad52-mediated DNA Annealing
TLDR
Regulation of Rad52-mediated annealing suggests a control function for Rad51 in deciding the recombination path taken for a processed DNA break; the ssDNA can be directed to either Rad51-mediated DNA strand invasion or to Rad 52- mediated DNA annealed.About:
This article is published in Journal of Biological Chemistry.The article was published on 2008-05-23 and is currently open access. It has received 93 citations till now. The article focuses on the topics: Replication protein A & Strand invasion.read more
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Dissertation
Purification And Characterization Of Proteins Important For Homologous Recombination In Eukaryotes
TL;DR: The purification of Trypanosoma brucei 7 BRC repeats rendered this protein highly soluble and stable based on circular dichroism spectroscopy which revealed the protein having poly-proline structure, a characteristic of unordered proteins.
Dissertation
A Genome-scale RNA Interference Screen Identifies Novel Regulators of DNA Double-strand Break Repair
TL;DR: This thesis describes the establishment of an immunofluorescence-based assay that monitors end resection by quantitative image-based cytometry (QIBC) and demonstrates that ZNF335 promotes DSB repair by HR through the enhancement of DNAend resection.
Role and regulation of homologous recombination in response to DNA double strand breaks and replication stress in Saccharomyces cerevisiae
TL;DR: In this article, the authors propose a method to solve the problem of "uniformity" and "uncertainty" in the context of video games.1.11.11
Journal ArticleDOI
Partner Choice in Spontaneous Mitotic Recombination in Wild Type and Homologous Recombination Mutants of Candida albicans.
TL;DR: The specific sizes of Chr6 truncations suggest that the inserted URA-blaster could represent a fragile site, and the type and frequency of mechanisms underlying direct repeat recombination varied greatly.
Dissertation
Investigation of mechanisms that suppress non-allelic homologous recombination
TL;DR: The types of repetitive sequences seen in eukaryotic genomes are outlined and how recombination mechanisms are regulated at the DNA sequence, cell organization, chromatin structure, and cell cycle control levels to prevent chromosomal rearrangements involving these sequences are outlined.
References
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
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Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Frédéric Pâques,James E. Haber +1 more
TL;DR: This review encompasses different aspects of DSB-induced recombination in Saccharomyces and attempts to relate genetic, molecular biological, and biochemical studies of the processes of DNA repair and recombination.
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Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair
TL;DR: An overview of recent biochemical and structural analyses of the Rad52 group proteins is provided and how this information can be incorporated into genetic studies of recombination is discussed.
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Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins
TL;DR: The cellular response to DSBs and DNA replication stress is likely directed by the Mre11 complex detecting and processing DNA ends in conjunction with Sae2 and by RP-A recognizing single-stranded DNA and recruiting additional checkpoint and repair proteins.
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DNA helicase Srs2 disrupts the Rad51 presynaptic filament
Lumir Krejci,Stephen Van Komen,Ying Li,Jana Villemain,Mothe Sreedhar Reddy,Hannah L. Klein,Thomas E. Ellenberger,Patrick Sung +7 more
TL;DR: The role of SRS2 in recombination modulation is clarified by purifying its encoded product and examining its interactions with the Rad51 recombinase, and it is shown that Srs2 acts by dislodging Rad51 from ssDNA.